TY  - JOUR
AU  - Abolhassani, Ayda
AU  - Alawathurage, T Madhusankha
AU  - Schmidt, Axel
AU  - Brand, Fabian
AU  - Kilarski, Laura L
AU  - Altmann, Heidi
AU  - Dahl, Edgar
AU  - Frank, Sandra
AU  - Göpel, Siri
AU  - Hanses, Frank
AU  - Hellmuth, Johannes Christian
AU  - Herr, Christian
AU  - Kaasch, Achim J
AU  - Kobbe, Robin
AU  - Konik, Margarethe Justine
AU  - Pink, Isabell
AU  - Römmele, Christoph
AU  - Rupp, Jan
AU  - Scheer, Christian S
AU  - Schneider, Marc A
AU  - Stellbrink, Christoph
AU  - Stubbe, Hans Christian
AU  - Tepasse, Phil-Robin
AU  - Teufel, Andreas
AU  - Vadász, István
AU  - Vehreschild, Maria J G T
AU  - Witzenrath, Martin
AU  - Anton, Gabriele
AU  - Bröhl, Isabel
AU  - Herold, Susanne
AU  - Illig, Thomas
AU  - Jiru-Hillmann, Steffi
AU  - Krawitz, Peter
AU  - Mitrov, Lazar
AU  - Philipsen, Alexandra
AU  - Pütz, Sina M
AU  - Noethen, Markus M
AU  - Nuernberg, Peter
AU  - Reese, Jens-Peter
AU  - Riess, Olaf
AU  - Schreiber, Stefan
AU  - Schultze, Joachim
AU  - Steinbeis, Fridolin
AU  - Vehreschild, J Janne
AU  - Wildberg, Christian
AU  - Ludwig, Kerstin U
AU  - Schulte, Eva C
TI  - Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).
JO  - Human genomics
VL  - 20
IS  - 1
SN  - 1473-9542
CY  - London [u.a.]
PB  - Henry Stewart Publ.
M1  - DZNE-2026-00131
SP  - 23
PY  - 2026
AB  - While genome-wide association studies (GWAS) have linked common genetic variants to COVID-19 susceptibility and severity, rare high-impact variants may also contribute to phenotypic heterogeneity. Inborn errors of type I interferon immunity (IFN-I-IEIs), including X-linked TLR7 deficiency, account for   2
KW  - Humans
KW  - COVID-19: genetics
KW  - COVID-19: epidemiology
KW  - COVID-19: virology
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Aged
KW  - Germany: epidemiology
KW  - Genome-Wide Association Study
KW  - SARS-CoV-2
KW  - Genetic Predisposition to Disease
KW  - Toll-Like Receptor 7: genetics
KW  - Cohort Studies
KW  - Severity of Illness Index
KW  - Comorbidity
KW  - Pandemics
KW  - Gene Frequency
KW  - Interferon Type I: genetics
KW  - Multifactorial Inheritance
KW  - Polymorphism, Single Nucleotide
KW  - Toll-Like Receptor 7 (NLM Chemicals)
KW  - TLR7 protein, human (NLM Chemicals)
KW  - Interferon Type I (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41578410
C2  - pmc:PMC12849158
DO  - DOI:10.1186/s40246-025-00904-9
UR  - https://pub.dzne.de/record/284363
ER  -