TY - JOUR AU - Komljenovic, Dorde AU - Bäuerle, Tobias AU - Alves-de-Lima, Jessica AU - Trigueros, Laura AU - Dietz, Cara AU - Winter, Zoltan AU - Araceli, Tommaso AU - Strotzer, Quirin AU - Wendl, Christina AU - Brendel, Matthias AU - Proescholdt, Martin A AU - Harter, Patrick N AU - Evert, Katja AU - Pukrop, Tobias AU - Blazquez, Raquel TI - Local metastatic expansion versus secondary intra-organ dissemination: two causes of neurological death explained by fundamentally different metastatic colonization patterns. JO - Molecular cancer VL - 25 IS - 1 SN - 1476-4598 CY - London PB - Biomed Central M1 - DZNE-2026-00132 SP - 17 PY - 2026 AB - Neurological failure contributes to 15-50 KW - Brain Neoplasms: secondary KW - Brain Neoplasms: pathology KW - Brain Neoplasms: diagnostic imaging KW - Animals KW - Humans KW - Mice KW - Neoplasm Metastasis KW - Disease Models, Animal KW - Female KW - Retrospective Studies KW - Male KW - Magnetic Resonance Imaging KW - Nervous System Diseases: etiology KW - Nervous System Diseases: pathology KW - Brain metastasis (Other) KW - Cause of death (Other) KW - Histological growth pattern (Other) KW - Infiltration (Other) KW - Local metastatic expansion (Other) KW - MMPI (Other) KW - Meningeal metastasis (Other) KW - Neurological decline (Other) KW - Recolonization (Other) KW - Secondary dissemination (Other) LB - PUB:(DE-HGF)16 C6 - pmid:41580751 C2 - pmc:PMC12849154 DO - DOI:10.1186/s12943-026-02574-0 UR - https://pub.dzne.de/record/284364 ER -