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000285001 1001_ $$0P:(DE-2719)9003150$$aStengl, Helena$$b0$$eFirst author
000285001 245__ $$aMyocardial injury in patients with acute ischemic stroke: Prevalence and types of triggers of myocardial demand ischemia.
000285001 260__ $$aLondon$$bSage Publishing$$c2026
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000285001 520__ $$aAcute myocardial injury occurs in about every fourth patient in the early phase after ischemic stroke. It may be caused by an imbalance between myocardial oxygen supply and demand, potentially leading to type 2 myocardial infarction (MI). However, little is known about the prevalence of potential triggers of such demand ischemia in acute stroke.Consecutive patients with and without post-stroke acute myocardial injury (elevated high-sensitivity cardiac troponin T [hs-cTnT] levels with a rise/fall >20%) were matched for age and sex and retrospectively screened for presence of predefined triggering conditions of myocardial demand ischemia and fulfillment of diagnostic criteria for acute MI.Among 508 stroke patients analyzed (median age 81 [73-86] years, 52% female), predefined potential triggers of demand ischemia were present in 107/254 (42%) patients with acute myocardial injury and in 61/254 (24%) matched controls (adjusted OR 2.30, 95%CI 1.51-3.52, p < 0.001). Patients with a trigger were older, more often female, had more severe strokes, and more often insular cortex involvement. The most prevalent triggers were respiratory failure, sustained hypertension, supraventricular tachyarrhythmia, and hemodynamic shock. MI criteria were fulfilled in 44/254 (17%) patients with acute myocardial injury including 27/44 (61.4%) with a trigger of demand ischemia (i.e. suspected type 2 MI).Conditions triggering a myocardial oxygen demand/supply mismatch are highly prevalent in patients with acute myocardial injury detected after stroke, notably in those fulfilling the criteria of acute MI. Stroke-specific aspects such as stroke severity or lesion location may play a role in the development of such triggers.
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000285001 650_7 $$2Other$$a4th UDMI
000285001 650_7 $$2Other$$aIschemic stroke
000285001 650_7 $$2Other$$aStroke-Heart Syndrome
000285001 650_7 $$2Other$$aacute myocardial injury
000285001 650_7 $$2Other$$acentral autonomic network%
000285001 650_7 $$2Other$$ademand ischemia
000285001 650_7 $$2Other$$ahigh-sensitivity cardiac troponin T
000285001 650_7 $$2Other$$atype 2 MI
000285001 650_7 $$2NLM Chemicals$$aTroponin T
000285001 650_2 $$2MeSH$$aHumans
000285001 650_2 $$2MeSH$$aFemale
000285001 650_2 $$2MeSH$$aMale
000285001 650_2 $$2MeSH$$aAged
000285001 650_2 $$2MeSH$$aIschemic Stroke: complications
000285001 650_2 $$2MeSH$$aIschemic Stroke: epidemiology
000285001 650_2 $$2MeSH$$aPrevalence
000285001 650_2 $$2MeSH$$aAged, 80 and over
000285001 650_2 $$2MeSH$$aRetrospective Studies
000285001 650_2 $$2MeSH$$aMyocardial Ischemia: epidemiology
000285001 650_2 $$2MeSH$$aMyocardial Ischemia: etiology
000285001 650_2 $$2MeSH$$aTroponin T: blood
000285001 650_2 $$2MeSH$$aMyocardial Infarction: epidemiology
000285001 650_2 $$2MeSH$$aMyocardial Infarction: etiology
000285001 650_2 $$2MeSH$$aStroke: complications
000285001 650_2 $$2MeSH$$aStroke: epidemiology
000285001 7001_ $$0P:(DE-2719)9003672$$aBöhme, Sophie$$b1$$udzne
000285001 7001_ $$aRichter, Oskar$$b2
000285001 7001_ $$aHellwig, Simon$$b3
000285001 7001_ $$00000-0002-8990-262X$$aKlammer, Markus G$$b4
000285001 7001_ $$aGaneshan, Ramanan$$b5
000285001 7001_ $$0P:(DE-HGF)0$$aReimann, Laura$$b6
000285001 7001_ $$00000-0002-4785-0366$$aAudebert, Heinrich J$$b7
000285001 7001_ $$00000-0001-7598-708X$$aDoehner, Wolfram$$b8
000285001 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian H$$b9
000285001 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b10
000285001 7001_ $$0P:(DE-2719)9001514$$aScheitz, Jan F$$b11
000285001 773__ $$0PERI:(DE-600)2851287-X$$a10.1093/esj/23969873251346008$$gVol. 11, no. 1, p. 23969873251346008$$n1$$p23969873251346008$$tEuropean stroke journal$$v11$$x2396-9873$$y2026
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