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@ARTICLE{Stengl:285001,
      author       = {Stengl, Helena and Böhme, Sophie and Richter, Oskar and
                      Hellwig, Simon and Klammer, Markus G and Ganeshan, Ramanan
                      and Reimann, Laura and Audebert, Heinrich J and Doehner,
                      Wolfram and Nolte, Christian H and Endres, Matthias and
                      Scheitz, Jan F},
      title        = {{M}yocardial injury in patients with acute ischemic stroke:
                      {P}revalence and types of triggers of myocardial demand
                      ischemia.},
      journal      = {European stroke journal},
      volume       = {11},
      number       = {1},
      issn         = {2396-9873},
      address      = {London},
      publisher    = {Sage Publishing},
      reportid     = {DZNE-2026-00135},
      pages        = {23969873251346008},
      year         = {2026},
      abstract     = {Acute myocardial injury occurs in about every fourth
                      patient in the early phase after ischemic stroke. It may be
                      caused by an imbalance between myocardial oxygen supply and
                      demand, potentially leading to type 2 myocardial infarction
                      (MI). However, little is known about the prevalence of
                      potential triggers of such demand ischemia in acute
                      stroke.Consecutive patients with and without post-stroke
                      acute myocardial injury (elevated high-sensitivity cardiac
                      troponin T [hs-cTnT] levels with a rise/fall $>20\%)$ were
                      matched for age and sex and retrospectively screened for
                      presence of predefined triggering conditions of myocardial
                      demand ischemia and fulfillment of diagnostic criteria for
                      acute MI.Among 508 stroke patients analyzed (median age 81
                      [73-86] years, $52\%$ female), predefined potential triggers
                      of demand ischemia were present in 107/254 $(42\%)$ patients
                      with acute myocardial injury and in 61/254 $(24\%)$ matched
                      controls (adjusted OR 2.30, $95\%CI$ 1.51-3.52, p < 0.001).
                      Patients with a trigger were older, more often female, had
                      more severe strokes, and more often insular cortex
                      involvement. The most prevalent triggers were respiratory
                      failure, sustained hypertension, supraventricular
                      tachyarrhythmia, and hemodynamic shock. MI criteria were
                      fulfilled in 44/254 $(17\%)$ patients with acute myocardial
                      injury including 27/44 $(61.4\%)$ with a trigger of demand
                      ischemia (i.e. suspected type 2 MI).Conditions triggering a
                      myocardial oxygen demand/supply mismatch are highly
                      prevalent in patients with acute myocardial injury detected
                      after stroke, notably in those fulfilling the criteria of
                      acute MI. Stroke-specific aspects such as stroke severity or
                      lesion location may play a role in the development of such
                      triggers.},
      keywords     = {Humans / Female / Male / Aged / Ischemic Stroke:
                      complications / Ischemic Stroke: epidemiology / Prevalence /
                      Aged, 80 and over / Retrospective Studies / Myocardial
                      Ischemia: epidemiology / Myocardial Ischemia: etiology /
                      Troponin T: blood / Myocardial Infarction: epidemiology /
                      Myocardial Infarction: etiology / Stroke: complications /
                      Stroke: epidemiology / 4th UDMI (Other) / Ischemic stroke
                      (Other) / Stroke-Heart Syndrome (Other) / acute myocardial
                      injury (Other) / central autonomic $network\%$ (Other) /
                      demand ischemia (Other) / high-sensitivity cardiac troponin
                      T (Other) / type 2 MI (Other) / Troponin T (NLM Chemicals)},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41614487},
      doi          = {10.1093/esj/23969873251346008},
      url          = {https://pub.dzne.de/record/285001},
}