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@ARTICLE{Weih:285002,
      author       = {Weih, Fiona and Rullmann, Michael and Henssen, Dylan and
                      Meyer, Philipp M and Jochimsen, Thies and Schildan, Andreas
                      and Rumpf, Jost-Julian and Brendel, Matthias and Schroeter,
                      Matthias L and Classen, Joseph and Barthel, Henryk and
                      Sabri, Osama and Tiepolt, Solveig},
      title        = {{H}ybrid {T}au-{PET}/{MRI} study: {Q}uantitative
                      susceptibility mapping in progressive supranuclear palsy and
                      its correlation with {T}au-{PET}.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {53},
      number       = {3},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DZNE-2026-00136},
      pages        = {2099 - 2109},
      year         = {2026},
      abstract     = {The atypical Parkinsonian disorder progressive supranuclear
                      palsy (PSP) forms a diagnostic challenge, resulting in
                      frequent misdiagnosis and delay in treatment. Although
                      structural MRI can detect PSP signs at more advanced stages,
                      emerging diagnostic tools such as tau-PET and quantitative
                      susceptibility mapping (QSM) may allow for earlier
                      detection. This exploratory study aimed to investigate
                      differences in QSM data of patients with PSP and healthy
                      controls (HCs) and for the first time assess possible
                      correlations between QSM and tau-PET data in patients with
                      PSP to explore the relationship between tau aggregation and
                      iron susceptibility.We retrospectively investigated
                      differences in susceptibility values of brain structures, as
                      assessed by QSM, between 11 HCs and 31 patients with PSP
                      [Richardson's syndrome (PSP-RS): n = 14; other subtypes
                      (PSP-nonRS): n = 17]. Additionally, we examined
                      co-registered [18F]PI-2620 PET and QSM data in the 31
                      patients with PSP to explore the relationship between tau
                      accumulation and susceptibility changes.Compared to HCs,
                      patients with PSP showed higher QSM values in left nucleus
                      caudate (p = 0.04) and bilateral dentate nucleus (p = 0.04,
                      p = 0.01). Patients with the subtype PSP-RS showed higher
                      QSM values than HCs in left dentate nucleus (p = 0.02). The
                      association between the patients' QSM and tau-PET data
                      showed a significant positive correlation.These results
                      suggest distinct patterns of regional iron accumulation in
                      patients with PSP and its subtypes and support an
                      association between iron and tau pathology. The data
                      encourage further investigation in longitudinal studies and
                      validation in larger cohorts to examine the value of QSM as
                      a possible diagnostic biomarker.},
      keywords     = {Humans / Supranuclear Palsy, Progressive: diagnostic
                      imaging / Supranuclear Palsy, Progressive: metabolism / Male
                      / Female / tau Proteins: metabolism / Magnetic Resonance
                      Imaging / Positron-Emission Tomography / Aged / Middle Aged
                      / Retrospective Studies / Multimodal Imaging / MRI (Other) /
                      PET (Other) / PSP (Other) / QSM (Other) / Tau (Other) / tau
                      Proteins (NLM Chemicals)},
      cin          = {AG Haass},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41174096},
      doi          = {10.1007/s00259-025-07600-9},
      url          = {https://pub.dzne.de/record/285002},
}