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@ARTICLE{Crook:285003,
      author       = {Crook, Harry and Franzmeier, Nicolai and Rahmouni, Nesrine
                      and Gnoerich, Johannes and Fryer, Tim D and Hong, Young T
                      and Roemer-Cassiano, Sebastian N and Palleis, Carla and
                      Strauss, Alexandra and Jones, P Simon and Aigbirhio,
                      Franklin I and Hopewell, Robert and Rauchmann, Boris Stephan
                      and Massarweh, Gassan and Perneczky, Robert and Levin,
                      Johannes and Höglinger, Günter U and Rowe, James B and
                      O'Brien, John T and Rosa-Neto, Pedro and Brendel, Matthias
                      and Malpetti, Maura},
      title        = {{C}omparing and combining {TSPO}-{PET} tracers in
                      tauopathies.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {53},
      number       = {3},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DZNE-2026-00137},
      pages        = {2083 - 2098},
      year         = {2026},
      abstract     = {Neuroinflammation is a key pathological driver in
                      neurodegenerative diseases, including Alzheimer's disease
                      (AD) and Progressive Supranuclear Palsy (PSP). Positron
                      emission tomography (PET) with tracers targeting the
                      translocator protein (TSPO) enables the in vivo
                      quantification of microgliosis. TSPO tracers have shown
                      similar disease-specific patterns across cohorts. However,
                      direct quantitative comparisons between commonly used
                      TSPO-PET tracers in tauopathies have not been performed.
                      Here, we apply a TSPO-PET standardization pipeline across
                      clinically matched AD cohorts and PSP cohorts, to quantify,
                      compare and combine multi-centre TSPO-PET data.Patients with
                      PSP were scanned with either [11C]PK11195 or [18F]GE-180 at
                      one of two centres, while patients with AD and control
                      participants were scanned with either [11C]PK11195,
                      [18F]GE-180 or [11C]PBR28 at one of three centres. A
                      standardised pre-processing pipeline was implemented and
                      participant standardised uptake volume ratio (SUVR) values
                      were z-scored using tracer-specific control participant
                      values. In a data-driven approach, dissimilarity analyses
                      were employed to assess differences between tracers across
                      clinically matched cohorts.In PSP, dissimilarity analysis
                      suggested that [11C]PK11195 and [18F]GE-180 binding patterns
                      were comparable following standardisation. In AD,
                      comparability across tracers was less robust, with
                      [11C]PK11195 and [18F]GE-180 being most comparable, followed
                      by [18F]GE-180 vs. [11C]PBR28, then by [11C]PK11195 vs.
                      [11C]PBR28.The pipeline was effective at harmonising
                      TSPO-PET tracers and standardising the regional
                      quantification of neuroinflammation in clinically matched
                      cohorts of PSP, while the standardisation pipeline results
                      were less robust across AD cohorts.},
      keywords     = {Humans / Positron-Emission Tomography: methods /
                      Positron-Emission Tomography: standards / Receptors, GABA:
                      metabolism / Male / Female / Aged / Middle Aged /
                      Radioactive Tracers / Tauopathies: diagnostic imaging /
                      Tauopathies: metabolism / Alzheimer Disease: diagnostic
                      imaging / Alzheimer Disease: metabolism /
                      Radiopharmaceuticals / Carbazoles / Isoquinolines /
                      Alzheimer’s disease. (Other) / Neuroinflammation (Other) /
                      Positron emission tomography (Other) / Progressive
                      supranuclear palsy (Other) / Translocator protein (Other) /
                      Receptors, GABA (NLM Chemicals) / TSPO protein, human (NLM
                      Chemicals) / Radioactive Tracers (NLM Chemicals) / PK 11195
                      (NLM Chemicals) / GE-180 (NLM Chemicals) /
                      Radiopharmaceuticals (NLM Chemicals) / Carbazoles (NLM
                      Chemicals) / Isoquinolines (NLM Chemicals)},
      cin          = {Clinical Research (Munich) / AG Dichgans / AG Levin / AG
                      Haass},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015 / I:(DE-2719)5000022 /
                      I:(DE-2719)1111016 / I:(DE-2719)1110007},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41114734},
      doi          = {10.1007/s00259-025-07579-3},
      url          = {https://pub.dzne.de/record/285003},
}