000285005 001__ 285005
000285005 005__ 20260202114302.0
000285005 0247_ $$2doi$$a10.1093/esj/23969873251360145
000285005 0247_ $$2pmid$$apmid:41614521
000285005 0247_ $$2ISSN$$a2396-9873
000285005 0247_ $$2ISSN$$a2396-9881
000285005 037__ $$aDZNE-2026-00139
000285005 041__ $$aEnglish
000285005 082__ $$a610
000285005 1001_ $$00000-0002-6798-1320$$aZhang, Lanyue$$b0
000285005 245__ $$aCirculating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study.
000285005 260__ $$aLondon$$bSage Publishing$$c2026
000285005 3367_ $$2DRIVER$$aarticle
000285005 3367_ $$2DataCite$$aOutput Types/Journal article
000285005 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1770028301_15531
000285005 3367_ $$2BibTeX$$aARTICLE
000285005 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000285005 3367_ $$00$$2EndNote$$aJournal Article
000285005 520__ $$aAnti-inflammatory therapies are tested in randomized trials for secondary stroke prevention. Detecting inflammatory biomarkers that predict vascular recurrence could optimize patient selection for these trials.In a multicenter prospective cohort study, we measured plasma levels of 22 inflammatory cytokines in 486 acute stroke patients (474 ischemic strokes and 12 intracerebral hemorrhages; median age 68 years, 34% female, median 3 days post-stroke onset). Patients were followed for over 5 years through telephone and in-person interviews to record the occurrence of the following outcomes: (1) recurrent stroke or transient ischemic attack (TIA; primary outcome); (2) a composite of recurrent vascular events (stroke, TIA, acute coronary syndrome, hospital admission due to heart failure, and death; secondary outcome). Associations between cytokine levels and these outcomes were analyzed using Cox proportional hazards models adjusted for demographic and vascular risk factors.During the 5-year follow-up period, 59 patients (12.1%) experienced recurrent stroke or TIA, and 118 (24.3%) experienced recurrent vascular events. After adjustments for demographic and vascular risk factors, and correction for multiple comparisons, higher plasma levels of CD62E (adjusted Hazard Ratio (aHR)/SD increment: 1.63, 95%CI 1.22-2.20) and MIF (aHR: 1.56, 95%CI 1.18-2.06) in the acute phase after stroke were statistically significantly associated with increased risk of recurrent stroke or TIA. The associations followed a dose-response pattern across quartiles of CD62E and MIF levels. Adding baseline CD62E and MIF levels to models including age, sex, vascular risk factors, and baseline C-reactive protein (CRP) levels led to significant improvements in the prediction of 5-year risk of recurrent stroke or TIA (ΔC-index 0.030-0.050).Among stroke patients, higher baseline levels of CD62E and MIF improved prediction of 5-year risk of recurrent stroke or TIA on top of vascular risk factors and CRP levels. Whether assessment of these cytokines could improve patient selection for secondary prevention trials of anti-inflammatory treatments, should be explored in future studies.
000285005 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000285005 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000285005 650_7 $$2Other$$aStroke
000285005 650_7 $$2Other$$acytokines
000285005 650_7 $$2Other$$ainflammation
000285005 650_7 $$2Other$$arecurrence
000285005 650_7 $$2Other$$arisk prediction
000285005 650_7 $$2NLM Chemicals$$aCytokines
000285005 650_7 $$2NLM Chemicals$$aBiomarkers
000285005 650_2 $$2MeSH$$aHumans
000285005 650_2 $$2MeSH$$aFemale
000285005 650_2 $$2MeSH$$aMale
000285005 650_2 $$2MeSH$$aAged
000285005 650_2 $$2MeSH$$aProspective Studies
000285005 650_2 $$2MeSH$$aRecurrence
000285005 650_2 $$2MeSH$$aMiddle Aged
000285005 650_2 $$2MeSH$$aCytokines: blood
000285005 650_2 $$2MeSH$$aIschemic Attack, Transient: blood
000285005 650_2 $$2MeSH$$aBiomarkers: blood
000285005 650_2 $$2MeSH$$aStroke: blood
000285005 650_2 $$2MeSH$$aFollow-Up Studies
000285005 650_2 $$2MeSH$$aRisk Factors
000285005 650_2 $$2MeSH$$aIschemic Stroke: blood
000285005 650_2 $$2MeSH$$aCohort Studies
000285005 7001_ $$aAntabi, Mohamad Ali$$b1
000285005 7001_ $$aMattar, Jana$$b2
000285005 7001_ $$aEl Bounkari, Omar$$b3
000285005 7001_ $$00000-0002-5663-9407$$aFang, Rong$$b4
000285005 7001_ $$0P:(DE-2719)2814124$$aWaegemann, Karin$$b5$$udzne
000285005 7001_ $$0P:(DE-2719)2811949$$aBode, Felix J$$b6
000285005 7001_ $$0P:(DE-2719)9000778$$aStösser, Sebastian$$b7$$udzne
000285005 7001_ $$0P:(DE-2719)2812183$$aHermann, Peter$$b8
000285005 7001_ $$0P:(DE-2719)9000189$$aLiman, Thomas G$$b9$$udzne
000285005 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian$$b10
000285005 7001_ $$aIkenberg, Benno$$b11
000285005 7001_ $$0P:(DE-HGF)0$$aBernkopf, Kathleen$$b12
000285005 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b13$$udzne
000285005 7001_ $$aBernhagen, Jürgen$$b14
000285005 7001_ $$0P:(DE-2719)2000030$$aDichgans, Martin$$b15
000285005 7001_ $$00000-0003-3507-3659$$aGeorgakis, Marios K$$b16
000285005 7001_ $$aInvestigators, DEMDAS$$b17$$eCollaboration Author
000285005 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b18$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b19$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2811628$$aKerti, Lucia$$b20$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2810407$$aNeumann, Katja$$b21$$eContributor$$udzne
000285005 7001_ $$aMeißner, Julius N$$b22$$eContributor
000285005 7001_ $$0P:(DE-2719)9000189$$aLiman, Thomas G.$$b23$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2811628$$aKerti, Lucia$$b24$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian H$$b25$$eContributor
000285005 7001_ $$aWittenberg, Tatjana$$b26$$eContributor
000285005 7001_ $$0P:(DE-2719)9001514$$aScheitz, Jan F$$b27$$eContributor
000285005 7001_ $$0P:(DE-2719)2810931$$aPrüß, Harald$$b28$$eContributor$$udzne
000285005 7001_ $$aSperber, Pia Sophie$$b29$$eContributor
000285005 7001_ $$aNave, Alexander H$$b30$$eContributor
000285005 7001_ $$aKufner Ibaroule, Anna$$b31$$eContributor
000285005 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b32$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2811949$$aBode, Felix$$b33$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)9000778$$aStösser, Sebastian$$b34$$eContributor$$udzne
000285005 7001_ $$aMeissner, Julius$$b35$$eContributor
000285005 7001_ $$0P:(DE-2719)9003076$$aEbrahimi, Taraneh$$b36$$eContributor$$udzne
000285005 7001_ $$aNordsiek, Julia$$b37$$eContributor
000285005 7001_ $$0P:(DE-2719)9002283$$aBeckonert, Niklas$$b38$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)9000373$$aKindler, Christine$$b39$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b40$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2812183$$aHermann, Peter$$b41$$eContributor
000285005 7001_ $$0P:(DE-2719)9000287$$aSchmitz, Matthias$$b42$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)9001986$$aGoebel, Stefan$$b43$$eContributor
000285005 7001_ $$aBunck, Timothy$$b44$$eContributor
000285005 7001_ $$aSchütte-Schmidt, Julia$$b45$$eContributor
000285005 7001_ $$aNuhn, Sabine$$b46$$eContributor
000285005 7001_ $$aVolpers, Corinna$$b47$$eContributor
000285005 7001_ $$aDechent, Peter$$b48$$eContributor
000285005 7001_ $$0P:(DE-2719)2811350$$aBähr, Mathias$$b49$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2811292$$aGörtler, Michael$$b50$$eContributor
000285005 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b51$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)9000985$$aPerosa, Valentina$$b52$$eContributor
000285005 7001_ $$0P:(DE-2719)2000030$$aDichgans, Martin$$b53$$eContributor$$udzne
000285005 7001_ $$aWollenweber, Frank$$b54$$eContributor
000285005 7001_ $$aGeorgakis, Marios$$b55$$eContributor
000285005 7001_ $$aFang, Rong$$b56$$eContributor
000285005 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b57$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2814124$$aWaegemann, Karin$$b58$$eContributor$$udzne
000285005 7001_ $$aTiedt, Steffen$$b59$$eContributor
000285005 7001_ $$aWunderlich, Silke$$b60$$eContributor
000285005 7001_ $$aIkenberg, Benno$$b61$$eContributor
000285005 7001_ $$aBernkopf, Kathleen$$b62$$eContributor
000285005 7001_ $$aHuber, Christiane$$b63$$eContributor
000285005 7001_ $$aPoppert, Holger$$b64$$eContributor
000285005 7001_ $$0P:(DE-2719)9000062$$aDüring, Marco$$b65$$eContributor
000285005 7001_ $$0P:(DE-2719)2812570$$aAraque Caballero, Miguel Ángel$$b66$$eContributor
000285005 7001_ $$0P:(DE-2719)9001112$$aGesierich, Benno$$b67$$eContributor$$udzne
000285005 7001_ $$aDewenter, Anna$$b68$$eContributor
000285005 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b69$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2810407$$aNeumann, Katja$$b70$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2810706$$aSpeck, Oliver$$b71$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b72$$eContributor$$udzne
000285005 7001_ $$0P:(DE-2719)2810538$$aStöcker, Tony$$b73$$eContributor$$udzne
000285005 7001_ $$aBartenstein, Peter$$b74$$eContributor
000285005 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b75$$eContributor$$udzne
000285005 773__ $$0PERI:(DE-600)2851287-X$$a10.1093/esj/23969873251360145$$gVol. 11, no. 1, p. 23969873251360145$$n1$$p23969873251360145$$tEuropean stroke journal$$v11$$x2396-9873$$y2026
000285005 8564_ $$uhttps://pub.dzne.de/record/285005/files/DZNE-2026-00139_Restricted.pdf
000285005 8564_ $$uhttps://pub.dzne.de/record/285005/files/DZNE-2026-00139_Restricted.pdf?subformat=pdfa$$xpdfa
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814124$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811949$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000778$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812183$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000189$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000234$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-HGF)0$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810273$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000285005 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000030$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811033$$aExternal Institute$$b18$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2000005$$aExternal Institute$$b19$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811628$$aExternal Institute$$b20$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810407$$aExternal Institute$$b21$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000189$$aExternal Institute$$b23$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811628$$aExternal Institute$$b24$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810931$$aExternal Institute$$b28$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810273$$aExternal Institute$$b32$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811949$$aExternal Institute$$b33$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000778$$aExternal Institute$$b34$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9003076$$aExternal Institute$$b36$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9002283$$aExternal Institute$$b38$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000373$$aExternal Institute$$b39$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2000058$$aExternal Institute$$b40$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000287$$aExternal Institute$$b42$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811350$$aExternal Institute$$b49$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811614$$aExternal Institute$$b51$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2000030$$aExternal Institute$$b53$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9002557$$aExternal Institute$$b57$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2814124$$aExternal Institute$$b58$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001112$$aExternal Institute$$b67$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811611$$aExternal Institute$$b69$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810407$$aExternal Institute$$b70$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810706$$aExternal Institute$$b71$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811324$$aExternal Institute$$b72$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810538$$aExternal Institute$$b73$$kExtern
000285005 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2000057$$aExternal Institute$$b75$$kExtern
000285005 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000285005 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2025-11-07$$wger
000285005 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEUR STROKE J : 2022$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-11-07
000285005 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bEUR STROKE J : 2022$$d2025-11-07
000285005 9201_ $$0I:(DE-2719)1111015$$kClinical Research (Munich)$$lClinical Research (Munich)$$x0
000285005 9201_ $$0I:(DE-2719)1013020$$kAG Petzold$$lVascular Neurology$$x1
000285005 9201_ $$0I:(DE-2719)1011001$$kClinical Research (Bonn)$$lClinical Research Coordination$$x2
000285005 9201_ $$0I:(DE-2719)1811005$$kAG Endres$$lInterdisciplinary Dementia Research$$x3
000285005 9201_ $$0I:(DE-2719)5000022$$kAG Dichgans$$lVascular Cognitive Impairment & Post-Stroke Dementia$$x4
000285005 980__ $$ajournal
000285005 980__ $$aEDITORS
000285005 980__ $$aVDBINPRINT
000285005 980__ $$aI:(DE-2719)1111015
000285005 980__ $$aI:(DE-2719)1013020
000285005 980__ $$aI:(DE-2719)1011001
000285005 980__ $$aI:(DE-2719)1811005
000285005 980__ $$aI:(DE-2719)5000022
000285005 980__ $$aUNRESTRICTED