%0 Journal Article
%A Hoenig, Merle C
%A Dzialas, Verena
%A Doering, Elena
%A Bischof, Gérard N
%A Eimeren, Thilo
%A Drzezga, Alexander
%T Modifiable Factors Associated with the Longitudinal Increase and Spatial Extent of Tau Pathology in Alzheimer Disease.
%J Journal of nuclear medicine
%V 67
%N 2
%@ 0097-9058
%C New York, NY
%I Soc.
%M DZNE-2026-00143
%P 291-296
%D 2026
%X There are 14 modifiable factors that are associated with a significantly lower risk of dementia. We tested the interactive effect of modifiable factors, genetic determinants, and initial pathologic burden on the spatial progression and local amplification of tau pathology. Methods: In total, 162 amyloid-positive individuals were included, for whom longitudinal [18F]AV-1451 PET scans, baseline information on global amyloid burden, ApoE4 status, body mass index (BMI), hypertension, education, neuropsychiatric symptom severity, and demographic information were available in the Alzheimer Disease Neuroimaging Initiative. All [18F]AV-1451 scans were intensity-standardized (reference: inferior cerebellum), z-transformed (control sample: 147 amyloid-negative subjects), thresholded (z score, >1.96), and converted to volume maps. Longitudinal tau changes were then assessed in terms of tau spatial extent (i.e., newly affected volume at follow-up) and tau level rise (i.e., tau increase in previously affected volume). These 2 measures were entered as dependent variables in linear mixed-effects models, including baseline modifiable risk factors (BMI, education, hypertension, neuropsychiatric symptom severity), global amyloid, tau volume or tau burden, ApoE4 status, clinical stage, sex, and age as predictors. Next, we tested the interactive effects between baseline amyloid or tau burden with the 4 modifiable factors on tau extent or tau level rise, respectively. Results: Greater tau extent was linked to higher BMI (β = 0.002; 95
%K Humans
%K tau Proteins: metabolism
%K Male
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: metabolism
%K Alzheimer Disease: pathology
%K Female
%K Aged
%K Longitudinal Studies
%K Positron-Emission Tomography
%K Carbolines
%K Aged, 80 and over
%K Middle Aged
%K Body Mass Index
%K Risk Factors
%K (non-)modifiable risk factors (Other)
%K spatial extent (Other)
%K tau pathology (Other)
%K tau Proteins (NLM Chemicals)
%K 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (NLM Chemicals)
%K Carbolines (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41266256
%2 pmc:PMC12866421
%R 10.2967/jnumed.125.270593
%U https://pub.dzne.de/record/285017