TY  - CONF
AU  - Lopez, Susanna
AU  - Hampel, Harald
AU  - Percio, Claudio Del
AU  - Noce, Giuseppe
AU  - Lizio, Roberta
AU  - Teipel, Stefan
AU  - Dyrba, Martin
AU  - Vergallo, Andrea
AU  - Ferri, Raffaele
AU  - Pardini, Matteo
AU  - Babiloni, Claudio
TI  - Older adults with subjective memory complaints and brain amyloidosis show stable electroencephalographic rhythms, cortical structure, and cognitive performances over 2 years
JO  - Alzheimer's and dementia
VL  - 21
IS  - S2
SN  - 1552-5260
M1  - DZNE-2026-00145
SP  - e106502
PY  - 2025
AB  - Background: It is well-known that in patients with Alzheimer's disease (AD) and high education attainment, cognitive performance is typically better than expected based on the burden of brain neuropathology and neurodegeneration (Stern et al., 2018; doi: 10.1016/j.neuroimage.2018.05.033). This resilience of the cognitive status was attributed to a sort of cognitive reserve (CR) accumulated by persons with high education attainment, which predicts a life with engaging job, intellectual, and social demands (Arenaza-Urquijo et al. 2015; doi: 10.3389/fnagi.2015.00134; Stern et al. 2018). Previous resting-state eyes-closed electroencephalographic (rsEEG) studies showed that alpha rhythms in posterior visual and visuospatial areas are related to CR in healthy adults, subjective memory complaints (SMC) seniors, and patients with mild cognitive impairment due to AD (ADMCI). Method: In the present exploratory study, we used the database of the INSIGHT cohort (Dubois et al., 2018; doi: 10.1016/S1474-4422(18)30029-2), we investigated whether older adults with subjective memory complaints (SMC) and brain amyloid-β accumulation may exhibit clinical progression over 2 years as a function of educational attainment (a proxy of cognitive reserve). Result: SMCneg with high educational attainment (Edu+) participants showed greater posterior rsEEG alpha rhythms compared to SMCneg with low educational attainment (Edu-) participants. In contrast, SMCpos Edu+ participants exhibited reduced posterior rsEEG alpha rhythms and parietal cortical thickness compared to SMCpos Edu- participants. No EEG (Figure 1) or MRI (Figure 2) marker significantly changed over the 2-year follow-up period. Conclusion: These findings suggest that a substantially longer time interval than 2 years should be assessed to evaluate the Alzheimer's disease progression and biomarker-guided targeted therapies in presymptomatic SMCpos adults.
T2  - Alzheimer’s Association International Conference
CY  - 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2  - 27 Jul 2025 - 31 Jul 2025
M2  - Toronto, Canada
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
DO  - DOI:10.1002/alz70856_106502
UR  - https://pub.dzne.de/record/285019
ER  -