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@INPROCEEDINGS{Lopez:285019,
      author       = {Lopez, Susanna and Hampel, Harald and Percio, Claudio Del
                      and Noce, Giuseppe and Lizio, Roberta and Teipel, Stefan and
                      Dyrba, Martin and Vergallo, Andrea and Ferri, Raffaele and
                      Pardini, Matteo and Babiloni, Claudio},
      title        = {{O}lder adults with subjective memory complaints and brain
                      amyloidosis show stable electroencephalographic rhythms,
                      cortical structure, and cognitive performances over 2 years},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {S2},
      issn         = {1552-5260},
      reportid     = {DZNE-2026-00145},
      pages        = {e106502},
      year         = {2025},
      abstract     = {Background: It is well-known that in patients with
                      Alzheimer's disease (AD) and high education attainment,
                      cognitive performance is typically better than expected
                      based on the burden of brain neuropathology and
                      neurodegeneration (Stern et al., 2018; doi:
                      10.1016/j.neuroimage.2018.05.033). This resilience of the
                      cognitive status was attributed to a sort of cognitive
                      reserve (CR) accumulated by persons with high education
                      attainment, which predicts a life with engaging job,
                      intellectual, and social demands (Arenaza-Urquijo et al.
                      2015; doi: 10.3389/fnagi.2015.00134; Stern et al. 2018).
                      Previous resting-state eyes-closed electroencephalographic
                      (rsEEG) studies showed that alpha rhythms in posterior
                      visual and visuospatial areas are related to CR in healthy
                      adults, subjective memory complaints (SMC) seniors, and
                      patients with mild cognitive impairment due to AD (ADMCI).
                      Method: In the present exploratory study, we used the
                      database of the INSIGHT cohort (Dubois et al., 2018; doi:
                      10.1016/S1474-4422(18)30029-2), we investigated whether
                      older adults with subjective memory complaints (SMC) and
                      brain amyloid-β accumulation may exhibit clinical
                      progression over 2 years as a function of educational
                      attainment (a proxy of cognitive reserve). Result: SMCneg
                      with high educational attainment (Edu+) participants showed
                      greater posterior rsEEG alpha rhythms compared to SMCneg
                      with low educational attainment (Edu-) participants. In
                      contrast, SMCpos Edu+ participants exhibited reduced
                      posterior rsEEG alpha rhythms and parietal cortical
                      thickness compared to SMCpos Edu- participants. No EEG
                      (Figure 1) or MRI (Figure 2) marker significantly changed
                      over the 2-year follow-up period. Conclusion: These findings
                      suggest that a substantially longer time interval than 2
                      years should be assessed to evaluate the Alzheimer's disease
                      progression and biomarker-guided targeted therapies in
                      presymptomatic SMCpos adults.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      cin          = {AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      doi          = {10.1002/alz70856_106502},
      url          = {https://pub.dzne.de/record/285019},
}