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000285021 037__ $$aDZNE-2026-00146
000285021 041__ $$aEnglish
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000285021 1001_ $$0P:(DE-HGF)0$$aNguyen, T. N.$$b0
000285021 245__ $$aThe Absence of Claudin-10 in the Enamel Organ Alters Its Integrity.
000285021 260__ $$aThousand Oaks, Calif.$$bSage$$c2026
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000285021 520__ $$aRare disorders related to tight junction (TJ) proteins have been associated with amelogenesis imperfecta. Pathogenic variants of CLDN10, encoding claudin-10b, a cation transport pore, cause the autosomal recessive HELIX syndrome (Hypohidrosis, Electrolyte imbalance, hypoLacrymia, Ichthyosis, Xerostomia). Patients exhibit salivary dysfunction and rapid enamel wear after tooth eruption. Since Cldn10 is expressed in the dental epithelium, this study explores the role of claudin-10b in amelogenesis. We analyzed amelogenesis in constitutive and conditional Cldn10 knockout (KO) murine models, comparing the findings to human HELIX enamel. First, analysis of constitutive Cldn10 knockout (KO) mice, which die within a few hours after birth, showed that claudin-10 is present at the plasma membrane of the stratum intermedium but not at the TJs during the secretory stage. Its absence altered gene expression related to ion transport and pH control, although without major disturbance in cell polarization or enamel matrix synthesis. Examination of later stages of amelogenesis in epithelium-targeted conditional Cldn10 KO mice showed that claudin-10 is present in the papillary layer at the maturation stage. In its absence, the pH of the enamel matrix was more basic during early maturation, suggesting that claudin-10 determines enamel matrix pH. However, at later stage of the maturation process, the pH was corrected and the resulting enamel did not show major structural or elemental alterations. These later findings were confirmed by exploring the enamel of Cldn10 KO transplanted tooth germs, which have developed in a controlled mineral environment. Nevertheless, higher contents of aluminum were detected in the enamel of transplanted germs and in human HELIX enamel, suggesting that claudin-10 deficiency may lead to a loss of enamel organ integrity. These data suggest that while salivary dysfunction is the main cause of enamel wear in HELIX, claudin-10 plays a direct role in amelogenesis by determining pH and enamel organ integrity.
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000285021 650_7 $$2Other$$aAluminum
000285021 650_7 $$2Other$$aAmeloblasts
000285021 650_7 $$2Other$$aAmelogenesis
000285021 650_7 $$2Other$$aGenetic disorders
000285021 650_7 $$2Other$$aIon transport
000285021 650_7 $$2Other$$aTight junctions
000285021 650_7 $$2NLM Chemicals$$aClaudins
000285021 650_7 $$2NLM Chemicals$$aclaudin 10
000285021 650_2 $$2MeSH$$aAnimals
000285021 650_2 $$2MeSH$$aClaudins: genetics
000285021 650_2 $$2MeSH$$aClaudins: physiology
000285021 650_2 $$2MeSH$$aClaudins: deficiency
000285021 650_2 $$2MeSH$$aMice, Knockout
000285021 650_2 $$2MeSH$$aMice
000285021 650_2 $$2MeSH$$aEnamel Organ: metabolism
000285021 650_2 $$2MeSH$$aAmelogenesis: genetics
000285021 650_2 $$2MeSH$$aAmelogenesis: physiology
000285021 650_2 $$2MeSH$$aHydrogen-Ion Concentration
000285021 650_2 $$2MeSH$$aTight Junctions
000285021 650_2 $$2MeSH$$aDental Enamel
000285021 650_2 $$2MeSH$$aHumans
000285021 7001_ $$aRibes, S.$$b1
000285021 7001_ $$00000-0002-0447-9616$$aAndrique, C.$$b2
000285021 7001_ $$aRequin, M.$$b3
000285021 7001_ $$00000-0002-6611-4380$$aBouchet, J.$$b4
000285021 7001_ $$aObtel, N.$$b5
000285021 7001_ $$aSlimani, L.$$b6
000285021 7001_ $$aBrouilly, N.$$b7
000285021 7001_ $$aTorrens, C.$$b8
000285021 7001_ $$0P:(DE-HGF)0$$aSchmitt, A.$$b9
000285021 7001_ $$00000-0001-5069-0730$$aGuilbert, T.$$b10
000285021 7001_ $$aMorawietz, M.$$b11
000285021 7001_ $$aKiesow, A.$$b12
000285021 7001_ $$00000-0001-6526-6481$$aBrunelle, A.$$b13
000285021 7001_ $$00000-0002-3896-314X$$aPercot, A.$$b14
000285021 7001_ $$aHadj-Rabia, S.$$b15
000285021 7001_ $$aGaucher, C.$$b16
000285021 7001_ $$aLe Bivic, A.$$b17
000285021 7001_ $$aHouillier, P.$$b18
000285021 7001_ $$aBardet, C.$$b19
000285021 7001_ $$0P:(DE-HGF)0$$aMuller, D.$$b20
000285021 7001_ $$aRamirez Rozzi, F.$$b21
000285021 7001_ $$00000-0003-3374-5722$$aCoradin, T.$$b22
000285021 7001_ $$0P:(DE-2719)9003035$$aBreiderhoff, T.$$b23
000285021 7001_ $$aChaussain, C.$$b24
000285021 773__ $$0PERI:(DE-600)2057074-0$$a10.1177/00220345251349109$$gVol. 105, no. 3, p. 385 - 395$$n3$$p385 - 395$$tJournal of dental research$$v105$$x0022-0345$$y2026
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