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000285022 037__ $$aDZNE-2026-00147
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000285022 1001_ $$aAarsland, Dag$$b0
000285022 245__ $$aPrevalence of Alzheimer's disease pathology in the community.
000285022 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2026
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000285022 520__ $$aThe prevalence of Alzheimer's disease neuropathological changes (ADNCs), the leading cause of cognitive impairment, remains uncertain. Recent blood-based biomarkers enable scalable assessment of ADNCs1. Here we measured phosphorylated tau at threonine 217 in 11,486 plasma samples from a Norwegian population-based cohort of individuals over 57 years of age as a surrogate marker for ADNCs. The estimated prevalence of ADNCs increased with age, from less than 8% in people 58-69.9 years of age to 65.2% in those over 90 years of age. Among participants aged 70 years or older, 10% had preclinical Alzheimer's disease, 10.4% had prodromal Alzheimer's disease and 9.8% had Alzheimer's disease dementia. Furthermore, among those 70 years of age or older, ADNCs were present in 60% of people with dementia, in 32.6% of those with mild cognitive impairment and in 23.5% of the cognitively unimpaired group. Our findings suggest a higher prevalence of Alzheimer's disease dementia in older individuals and a lower prevalence of preclinical Alzheimer's disease in younger groups than previously estimated2.
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000285022 650_7 $$2NLM Chemicals$$atau Proteins
000285022 650_7 $$2NLM Chemicals$$aBiomarkers
000285022 650_2 $$2MeSH$$aHumans
000285022 650_2 $$2MeSH$$aAlzheimer Disease: epidemiology
000285022 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000285022 650_2 $$2MeSH$$aAlzheimer Disease: blood
000285022 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000285022 650_2 $$2MeSH$$aAged
000285022 650_2 $$2MeSH$$aPrevalence
000285022 650_2 $$2MeSH$$aAged, 80 and over
000285022 650_2 $$2MeSH$$aMale
000285022 650_2 $$2MeSH$$aFemale
000285022 650_2 $$2MeSH$$atau Proteins: blood
000285022 650_2 $$2MeSH$$atau Proteins: chemistry
000285022 650_2 $$2MeSH$$aNorway: epidemiology
000285022 650_2 $$2MeSH$$aCognitive Dysfunction: epidemiology
000285022 650_2 $$2MeSH$$aCognitive Dysfunction: blood
000285022 650_2 $$2MeSH$$aCognitive Dysfunction: pathology
000285022 650_2 $$2MeSH$$aMiddle Aged
000285022 650_2 $$2MeSH$$aPhosphorylation
000285022 650_2 $$2MeSH$$aCohort Studies
000285022 650_2 $$2MeSH$$aBiomarkers: blood
000285022 650_2 $$2MeSH$$aAge Factors
000285022 7001_ $$00000-0003-0854-470X$$aSunde, Anita Lenora$$b1
000285022 7001_ $$00000-0003-3490-9899$$aTovar-Rios, Diego A$$b2
000285022 7001_ $$aLeuzy, Antoine$$b3
000285022 7001_ $$00000-0002-9984-9797$$aFladby, Tormod$$b4
000285022 7001_ $$00000-0003-3930-4354$$aZetterberg, Henrik$$b5
000285022 7001_ $$00000-0002-1890-4193$$aBlennow, Kaj$$b6
000285022 7001_ $$00000-0002-9092-2118$$aTan, Kübra$$b7
000285022 7001_ $$aDe Santis, Giovanni$$b8
000285022 7001_ $$aYakoub, Yara$$b9
000285022 7001_ $$aArslan, Burak$$b10
000285022 7001_ $$0P:(DE-2719)9003257$$aHuber, Hanna$$b11
000285022 7001_ $$aPola, Ilaria$$b12
000285022 7001_ $$aGrötschel, Lana$$b13
000285022 7001_ $$00009-0001-5339-933X$$aDi Molfetta, Guglielmo$$b14
000285022 7001_ $$00000-0003-3067-0016$$aSkjellegrind, Håvard K$$b15
000285022 7001_ $$00000-0001-6511-8219$$aSelbaek, Geir$$b16
000285022 7001_ $$aAshton, Nicholas J$$b17
000285022 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/s41586-025-09841-y$$gVol. 650, no. 8100, p. 182 - 186$$n8100$$p182 - 186$$tNature$$v650$$x0028-0836$$y2026
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