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024 7 _ |a 10.1038/s41586-025-09841-y
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024 7 _ |a 1476-4687
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037 _ _ |a DZNE-2026-00147
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Aarsland, Dag
|b 0
245 _ _ |a Prevalence of Alzheimer's disease pathology in the community.
260 _ _ |a London [u.a.]
|c 2026
|b Nature Publ. Group
336 7 _ |a article
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520 _ _ |a The prevalence of Alzheimer's disease neuropathological changes (ADNCs), the leading cause of cognitive impairment, remains uncertain. Recent blood-based biomarkers enable scalable assessment of ADNCs1. Here we measured phosphorylated tau at threonine 217 in 11,486 plasma samples from a Norwegian population-based cohort of individuals over 57 years of age as a surrogate marker for ADNCs. The estimated prevalence of ADNCs increased with age, from less than 8% in people 58-69.9 years of age to 65.2% in those over 90 years of age. Among participants aged 70 years or older, 10% had preclinical Alzheimer's disease, 10.4% had prodromal Alzheimer's disease and 9.8% had Alzheimer's disease dementia. Furthermore, among those 70 years of age or older, ADNCs were present in 60% of people with dementia, in 32.6% of those with mild cognitive impairment and in 23.5% of the cognitively unimpaired group. Our findings suggest a higher prevalence of Alzheimer's disease dementia in older individuals and a lower prevalence of preclinical Alzheimer's disease in younger groups than previously estimated2.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 7 |a Biomarkers
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease: epidemiology
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: blood
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnosis
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Prevalence
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a tau Proteins: blood
|2 MeSH
650 _ 2 |a tau Proteins: chemistry
|2 MeSH
650 _ 2 |a Norway: epidemiology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: epidemiology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: blood
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Phosphorylation
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Biomarkers: blood
|2 MeSH
650 _ 2 |a Age Factors
|2 MeSH
700 1 _ |a Sunde, Anita Lenora
|0 0000-0003-0854-470X
|b 1
700 1 _ |a Tovar-Rios, Diego A
|0 0000-0003-3490-9899
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700 1 _ |a Leuzy, Antoine
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700 1 _ |a Fladby, Tormod
|0 0000-0002-9984-9797
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700 1 _ |a Zetterberg, Henrik
|0 0000-0003-3930-4354
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700 1 _ |a Blennow, Kaj
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700 1 _ |a Tan, Kübra
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700 1 _ |a De Santis, Giovanni
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700 1 _ |a Yakoub, Yara
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700 1 _ |a Arslan, Burak
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700 1 _ |a Huber, Hanna
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700 1 _ |a Pola, Ilaria
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700 1 _ |a Grötschel, Lana
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700 1 _ |a Di Molfetta, Guglielmo
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700 1 _ |a Skjellegrind, Håvard K
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700 1 _ |a Selbaek, Geir
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700 1 _ |a Ashton, Nicholas J
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773 _ _ |a 10.1038/s41586-025-09841-y
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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