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000285024 0247_ $$2ISSN$$a1098-1063
000285024 037__ $$aDZNE-2026-00149
000285024 041__ $$aEnglish
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000285024 1001_ $$00000-0002-9980-154X$$aDaugherty, Ana M$$b0
000285024 245__ $$aHarmonized Protocol for Subfield Segmentation in the Hippocampal Body on High-Resolution In Vivo MRI From the Hippocampal Subfields Group (HSG).
000285024 260__ $$aNew York, NY [u.a.]$$bWiley$$c2026
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000285024 520__ $$aHippocampal subfields differentially develop and age, and they vary in vulnerability to neurodegenerative diseases. Innovation in high-resolution imaging has accelerated clinical research on human hippocampal subfields, but substantial differences in segmentation protocols impede comparisons of results across laboratories. The Hippocampal Subfields Group (HSG) is an international organization seeking to address this issue by developing a histologically valid, reliable, and freely available segmentation protocol for high-resolution T2-weighted 3 T MRI (http://www.hippocampalsubfields.com). Here, we report the first portion of the protocol focused on subfields in the hippocampal body; protocols for the head and tail are in development. The body protocol includes definitions of the internal boundaries between subiculum, Cornu Ammonis (CA) 1-3 subfields, and dentate gyrus, in addition to the external boundaries of the hippocampus apart from surrounding white matter and cerebrospinal fluid. The segmentation protocol is based on a novel histological reference dataset labeled by multiple expert neuroanatomists. With broad participation of the research community, we voted on the segmentation protocol via an online survey, which included detailed protocol information, feasibility testing, demonstration videos, example segmentations, and labeled histology. All boundary definitions were rated as having high clarity and reached consensus agreement by Delphi procedure. The harmonized body protocol yielded high inter- and intra-rater reliability. In the present paper we report the procedures to develop and test the protocol, as well as the detailed procedures for manual segmentation using the harmonized protocol. The harmonized protocol will significantly facilitate cross-study comparisons and provide increased insight into the structure and function of hippocampal subfields across the lifespan and in neurodegenerative diseases.
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000285024 650_7 $$2Other$$aCornu Ammonis
000285024 650_7 $$2Other$$adentate gyrus
000285024 650_7 $$2Other$$aneuroimaging
000285024 650_7 $$2Other$$asubiculum
000285024 650_2 $$2MeSH$$aHippocampus: diagnostic imaging
000285024 650_2 $$2MeSH$$aHippocampus: anatomy & histology
000285024 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000285024 650_2 $$2MeSH$$aMagnetic Resonance Imaging: standards
000285024 650_2 $$2MeSH$$aHumans
000285024 650_2 $$2MeSH$$aImage Processing, Computer-Assisted: methods
000285024 650_2 $$2MeSH$$aMale
000285024 650_2 $$2MeSH$$aFemale
000285024 7001_ $$aCarr, Valerie$$b1
000285024 7001_ $$00000-0002-0366-1555$$aCanada, Kelsey L$$b2
000285024 7001_ $$aRådman, Gustaf$$b3
000285024 7001_ $$aBrown, Thackery$$b4
000285024 7001_ $$aAugustinack, Jean$$b5
000285024 7001_ $$aAmunts, Katrin$$b6
000285024 7001_ $$aBakker, Arnold$$b7
000285024 7001_ $$0P:(DE-2719)2812972$$aBerron, David$$b8$$udzne
000285024 7001_ $$aBurggren, Alison$$b9
000285024 7001_ $$aChetelat, Gael$$b10
000285024 7001_ $$ade Flores, Robin$$b11
000285024 7001_ $$aDing, Song-Lin$$b12
000285024 7001_ $$aHuang, Yushan$$b13
000285024 7001_ $$aJohnson, Elliott$$b14
000285024 7001_ $$aKanel, Prabesh$$b15
000285024 7001_ $$00000-0002-2115-9534$$aKeresztes, Attila$$b16
000285024 7001_ $$aKedo, Olga$$b17
000285024 7001_ $$00000-0001-5373-9026$$aKennedy, Kristen M$$b18
000285024 7001_ $$00000-0002-0479-0156$$aLee, Joshua$$b19
000285024 7001_ $$00000-0002-7691-5050$$aMalykhin, Nikolai$$b20
000285024 7001_ $$aMartinez, Anjelica$$b21
000285024 7001_ $$aMueller, Susanne$$b22
000285024 7001_ $$aMulligan, Elizabeth$$b23
000285024 7001_ $$aOfen, Noa$$b24
000285024 7001_ $$aPalombo, Daniela$$b25
000285024 7001_ $$00000-0002-7899-7061$$aPasquini, Lorenzo$$b26
000285024 7001_ $$aPluta, John$$b27
000285024 7001_ $$00000-0002-5080-2138$$aRaz, Naftali$$b28
000285024 7001_ $$aRiggins, Tracy$$b29
000285024 7001_ $$aRodrigue, Karen M$$b30
000285024 7001_ $$00009-0006-8987-1778$$aSaifullah, Samaah$$b31
000285024 7001_ $$00000-0002-5433-8870$$aSchlichting, Margaret L$$b32
000285024 7001_ $$aStark, Craig$$b33
000285024 7001_ $$aWang, Lei$$b34
000285024 7001_ $$00000-0001-8543-4016$$aYushkevich, Paul$$b35
000285024 7001_ $$aLa Joie, Renaud$$b36
000285024 7001_ $$aWisse, Laura$$b37
000285024 7001_ $$00000-0002-2918-4152$$aOlsen, Rosanna$$b38
000285024 7001_ $$aInitiative, Alzheimer’s Disease Neuroimaging$$b39$$eCollaboration Author
000285024 7001_ $$aGroup, Hippocampal Subfields$$b40$$eCollaboration Author
000285024 773__ $$0PERI:(DE-600)1498049-6$$a10.1002/hipo.70073$$gVol. 36, no. 2, p. e70073$$n2$$pe70073$$tHippocampus$$v36$$x1050-9631$$y2026
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