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@ARTICLE{Daugherty:285024,
      author       = {Daugherty, Ana M and Carr, Valerie and Canada, Kelsey L and
                      Rådman, Gustaf and Brown, Thackery and Augustinack, Jean
                      and Amunts, Katrin and Bakker, Arnold and Berron, David and
                      Burggren, Alison and Chetelat, Gael and de Flores, Robin and
                      Ding, Song-Lin and Huang, Yushan and Johnson, Elliott and
                      Kanel, Prabesh and Keresztes, Attila and Kedo, Olga and
                      Kennedy, Kristen M and Lee, Joshua and Malykhin, Nikolai and
                      Martinez, Anjelica and Mueller, Susanne and Mulligan,
                      Elizabeth and Ofen, Noa and Palombo, Daniela and Pasquini,
                      Lorenzo and Pluta, John and Raz, Naftali and Riggins, Tracy
                      and Rodrigue, Karen M and Saifullah, Samaah and Schlichting,
                      Margaret L and Stark, Craig and Wang, Lei and Yushkevich,
                      Paul and La Joie, Renaud and Wisse, Laura and Olsen,
                      Rosanna},
      collaboration = {Initiative, Alzheimer’s Disease Neuroimaging and Group,
                      Hippocampal Subfields},
      title        = {{H}armonized {P}rotocol for {S}ubfield {S}egmentation in
                      the {H}ippocampal {B}ody on {H}igh-{R}esolution {I}n {V}ivo
                      {MRI} {F}rom the {H}ippocampal {S}ubfields {G}roup ({HSG}).},
      journal      = {Hippocampus},
      volume       = {36},
      number       = {2},
      issn         = {1050-9631},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2026-00149},
      pages        = {e70073},
      year         = {2026},
      abstract     = {Hippocampal subfields differentially develop and age, and
                      they vary in vulnerability to neurodegenerative diseases.
                      Innovation in high-resolution imaging has accelerated
                      clinical research on human hippocampal subfields, but
                      substantial differences in segmentation protocols impede
                      comparisons of results across laboratories. The Hippocampal
                      Subfields Group (HSG) is an international organization
                      seeking to address this issue by developing a histologically
                      valid, reliable, and freely available segmentation protocol
                      for high-resolution T2-weighted 3 T MRI
                      (http://www.hippocampalsubfields.com). Here, we report the
                      first portion of the protocol focused on subfields in the
                      hippocampal body; protocols for the head and tail are in
                      development. The body protocol includes definitions of the
                      internal boundaries between subiculum, Cornu Ammonis (CA)
                      1-3 subfields, and dentate gyrus, in addition to the
                      external boundaries of the hippocampus apart from
                      surrounding white matter and cerebrospinal fluid. The
                      segmentation protocol is based on a novel histological
                      reference dataset labeled by multiple expert
                      neuroanatomists. With broad participation of the research
                      community, we voted on the segmentation protocol via an
                      online survey, which included detailed protocol information,
                      feasibility testing, demonstration videos, example
                      segmentations, and labeled histology. All boundary
                      definitions were rated as having high clarity and reached
                      consensus agreement by Delphi procedure. The harmonized body
                      protocol yielded high inter- and intra-rater reliability. In
                      the present paper we report the procedures to develop and
                      test the protocol, as well as the detailed procedures for
                      manual segmentation using the harmonized protocol. The
                      harmonized protocol will significantly facilitate
                      cross-study comparisons and provide increased insight into
                      the structure and function of hippocampal subfields across
                      the lifespan and in neurodegenerative diseases.},
      keywords     = {Hippocampus: diagnostic imaging / Hippocampus: anatomy $\&$
                      histology / Magnetic Resonance Imaging: methods / Magnetic
                      Resonance Imaging: standards / Humans / Image Processing,
                      Computer-Assisted: methods / Male / Female / Cornu Ammonis
                      (Other) / dentate gyrus (Other) / neuroimaging (Other) /
                      subiculum (Other)},
      cin          = {AG Berron},
      ddc          = {610},
      cid          = {I:(DE-2719)5000070},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41635209},
      doi          = {10.1002/hipo.70073},
      url          = {https://pub.dzne.de/record/285024},
}