TY  - JOUR
AU  - Zhilina, Diana
AU  - Bolaños Castro, Lizbeth A
AU  - Eguiguren, Juan Sebastian
AU  - Zocher, Sara
AU  - Karasinsky, Anne
AU  - Widmer, Dimitri
AU  - Espinós, Alexandre
AU  - Borrell, Victor
AU  - Brand, Michael
AU  - Miura, Kyoko
AU  - Zierau, Oliver
AU  - Yun, Maximina H
AU  - Toda, Tomohisa
TI  - Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain.
JO  - Developmental dynamics
VL  - 255
IS  - 2
SN  - 1058-8388
CY  - New York, NY [u.a.]
PB  - Wiley
M1  - DZNE-2026-00154
SP  - 187 - 208
PY  - 2026
AB  - In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity. In contrast, other vertebrates such as salamanders and zebrafish exhibit a widely distributed neurogenic niches throughout the brain, suggesting a greater neurogenic capacity in adulthood. However, the mechanisms underlying this divergence in neurogenic potential among vertebrates remain elusive. To address this, we examined the expression dynamics of a critical epigenetic regulator for the long-term maintenance of murine ANSPCs, lamin B1, during adult neurogenesis across the vertebrate spectrum.Lamin B1 expression patterns during adult neurogenesis are conserved among mammals including mouse, naked mole-rat, and ferret. However, these patterns differ between mammals and anamniotes. In mammals, neural stem cells and neuroblasts exhibited higher lamin B1 levels, and differentiated neurons possessed lower lamin B1 levels. On the other hand, anamniotes showed the opposite patterns of lamin B1 expression, with higher levels in neurons compared to stem cells.Our study shows that the lamin B1 expression pattern during adult neurogenesis differs between species, and that changes in lamin B1 protein sequence may contribute to the differences in lamin B1 expression patterns. This study highlights potential differences in cell-autonomous epigenetic regulation in the maintenance of ANSPC pools in the adult brain among species.
KW  - Animals
KW  - Neurogenesis: physiology
KW  - Neurogenesis: genetics
KW  - Lamin Type B: metabolism
KW  - Lamin Type B: genetics
KW  - Brain: metabolism
KW  - Brain: cytology
KW  - Mice
KW  - Neural Stem Cells: metabolism
KW  - Neural Stem Cells: cytology
KW  - Neurons: metabolism
KW  - Vertebrates
KW  - adult neurogenesis (Other)
KW  - lamin B1 (Other)
KW  - nuclear lamina (Other)
KW  - Lamin Type B (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40214400
DO  - DOI:10.1002/dvdy.70023
UR  - https://pub.dzne.de/record/285029
ER  -