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@ARTICLE{Zhilina:285029,
      author       = {Zhilina, Diana and Bolaños Castro, Lizbeth A and
                      Eguiguren, Juan Sebastian and Zocher, Sara and Karasinsky,
                      Anne and Widmer, Dimitri and Espinós, Alexandre and
                      Borrell, Victor and Brand, Michael and Miura, Kyoko and
                      Zierau, Oliver and Yun, Maximina H and Toda, Tomohisa},
      title        = {{D}ynamic expression of lamin {B}1 during adult
                      neurogenesis in the vertebrate brain.},
      journal      = {Developmental dynamics},
      volume       = {255},
      number       = {2},
      issn         = {1058-8388},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2026-00154},
      pages        = {187 - 208},
      year         = {2026},
      abstract     = {In mammals, specific brain regions such as the dentate
                      gyrus (DG) of the hippocampus and the subventricular zone
                      (SVZ) of the lateral ventricles harbor adult neural
                      stem/progenitor cells (ANSPCs) that give rise to new neurons
                      and contribute to structural and functional brain
                      plasticity. In contrast, other vertebrates such as
                      salamanders and zebrafish exhibit a widely distributed
                      neurogenic niches throughout the brain, suggesting a greater
                      neurogenic capacity in adulthood. However, the mechanisms
                      underlying this divergence in neurogenic potential among
                      vertebrates remain elusive. To address this, we examined the
                      expression dynamics of a critical epigenetic regulator for
                      the long-term maintenance of murine ANSPCs, lamin B1, during
                      adult neurogenesis across the vertebrate spectrum.Lamin B1
                      expression patterns during adult neurogenesis are conserved
                      among mammals including mouse, naked mole-rat, and ferret.
                      However, these patterns differ between mammals and
                      anamniotes. In mammals, neural stem cells and neuroblasts
                      exhibited higher lamin B1 levels, and differentiated neurons
                      possessed lower lamin B1 levels. On the other hand,
                      anamniotes showed the opposite patterns of lamin B1
                      expression, with higher levels in neurons compared to stem
                      cells.Our study shows that the lamin B1 expression pattern
                      during adult neurogenesis differs between species, and that
                      changes in lamin B1 protein sequence may contribute to the
                      differences in lamin B1 expression patterns. This study
                      highlights potential differences in cell-autonomous
                      epigenetic regulation in the maintenance of ANSPC pools in
                      the adult brain among species.},
      keywords     = {Animals / Neurogenesis: physiology / Neurogenesis: genetics
                      / Lamin Type B: metabolism / Lamin Type B: genetics / Brain:
                      metabolism / Brain: cytology / Mice / Neural Stem Cells:
                      metabolism / Neural Stem Cells: cytology / Neurons:
                      metabolism / Vertebrates / adult neurogenesis (Other) /
                      lamin B1 (Other) / nuclear lamina (Other) / Lamin Type B
                      (NLM Chemicals)},
      cin          = {AG Toda},
      ddc          = {610},
      cid          = {I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40214400},
      doi          = {10.1002/dvdy.70023},
      url          = {https://pub.dzne.de/record/285029},
}