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@ARTICLE{DSouza:285034,
      author       = {D'Souza, Simone and Tekampe, Esther and Falkenburger,
                      Björn and Schnalke, Nils},
      title        = {{F}ear of progression in {P}arkinson's disease: {R}ole of
                      age and occupational status.},
      journal      = {Journal of Parkinson's Disease},
      volume       = {16},
      number       = {1},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2026-00159},
      pages        = {170 - 176},
      year         = {2026},
      abstract     = {Background: Parkinson's disease (PD) is a slowly
                      progressing neurodegenerative disorder, so it is likely that
                      people with PD (PwPD) face increasing disability. PwPD thus
                      experience various degrees of fear of progression (FoP),
                      which can become dysfunctional. Objective: This study aims
                      to examine the prevalence of and contributing factors to
                      dysfunctional FoP in PwPD. Methods: The Fear of Progression
                      Questionnaire-Short Form (FoP-Q-SF) was administered along
                      with further questionnaires for non-motor symptoms; PD motor
                      symptoms as reported by the Unified Parkinson's Disease
                      Rating Scale Part III (UPDRS III) were obtained from patient
                      charts. Results: $28\%$ of the 105 PwPD (mean age 66 years,
                      $56\%$ Hoehn $\&$ Yahr stage I/II) were categorized as
                      experiencing dysfunctional levels of FoP using the
                      established cut-off score of ≥34. Our analyses revealed
                      that the FoP-Q-SF underestimates the prevalence of
                      dysfunctional FoP in older and non-working PwPD. Using a
                      more appropriate cut-off, $33\%$ of PwPD are classified as
                      having dysfunctional levels of FoP. We found strong
                      correlations of FoP with measures of anxiety, depression and
                      quality of life. Disease duration was secondary to these
                      factors. We found no associations between FoP and motor
                      symptoms. Conclusions: Our findings confirm that
                      dysfunctional FoP significantly impacts the psychological
                      well-being of PwPD, affecting one in three PwPD and
                      contributing to heightened anxiety, depression, and reduced
                      quality of life. Future validation studies are needed to
                      confirm the cut-off value proposed here and to enable a
                      better integration of the concept of FoP into routine care
                      for PwPD.},
      keywords     = {Humans / Parkinson Disease: psychology / Parkinson Disease:
                      physiopathology / Aged / Male / Female / Disease Progression
                      / Middle Aged / Fear: psychology / Age Factors / Employment:
                      statistics $\&$ numerical data / Employment: psychology /
                      Anxiety: psychology / Anxiety: epidemiology / Quality of
                      Life: psychology / Aged, 80 and over / Depression:
                      psychology / Depression: epidemiology / Surveys and
                      Questionnaires / Parkinson's disease (Other) / anxiety
                      (Other) / depression (Other) / distress (Other) / fear of
                      progression (Other) / non-motor symptoms (Other)},
      cin          = {AG Falkenburger},
      ddc          = {610},
      cid          = {I:(DE-2719)1710012},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41252262},
      doi          = {10.1177/1877718X251365243},
      url          = {https://pub.dzne.de/record/285034},
}