000285038 001__ 285038
000285038 005__ 20260309111159.0
000285038 0247_ $$2doi$$a10.1016/j.pneurobio.2026.102882
000285038 0247_ $$2ISSN$$a0301-0082
000285038 0247_ $$2ISSN$$a1873-5118
000285038 037__ $$aDZNE-2026-00162
000285038 041__ $$aEnglish
000285038 082__ $$a610
000285038 1001_ $$aBruentgens, Felicitas$$b0
000285038 245__ $$aThe flexible synapse – How mossy fiber architecture adapts to changing needs
000285038 260__ $$aJena$$bElsevier$$c2026
000285038 3367_ $$2DRIVER$$aarticle
000285038 3367_ $$2DataCite$$aOutput Types/Journal article
000285038 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1773044754_14561$$xReview Article
000285038 3367_ $$2BibTeX$$aARTICLE
000285038 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000285038 3367_ $$00$$2EndNote$$aJournal Article
000285038 520__ $$aHippocampal mossy fiber boutons are unique, highly plastic synapses within the hippocampal circuitry. Despite mossy fiber bouton's potential role in learning and memory processes, the precise underlying mechanisms leading to their strengthened synaptic connections are still not fully understood. Here, we provide an overview of the structural changes occurring during long-term potentiation of large presynaptic terminals formed by mossy fiber onto CA3 pyramidal cells. Such changes encompass (1) adaptations in the number, shape and size of the bouton; (2) changes in availability of synaptic vesicles as well as the number and occupancy of release sites within single boutons; and (3) nano-architectural changes in the molecular composition and spatial arrangements within active zones. We describe these changes and possible implications for mossy fiber function. Furthermore, we discuss open questions, current methodology, and possible future directions.
000285038 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000285038 588__ $$aDataset connected to CrossRef, Journals: pub.dzne.de
000285038 650_7 $$2Other$$aHippocampus
000285038 650_7 $$2Other$$aLTP
000285038 650_7 $$2Other$$aMossy fibers
000285038 650_7 $$2Other$$aPresynaptic terminals
000285038 650_7 $$2Other$$aStructural plasticity
000285038 650_7 $$2Other$$aSynaptic plasticity
000285038 650_2 $$2MeSH$$aMossy Fibers, Hippocampal: physiology
000285038 650_2 $$2MeSH$$aMossy Fibers, Hippocampal: ultrastructure
000285038 650_2 $$2MeSH$$aAnimals
000285038 650_2 $$2MeSH$$aSynapses: physiology
000285038 650_2 $$2MeSH$$aSynapses: ultrastructure
000285038 650_2 $$2MeSH$$aHumans
000285038 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000285038 650_2 $$2MeSH$$aLong-Term Potentiation: physiology
000285038 650_2 $$2MeSH$$aPresynaptic Terminals: physiology
000285038 650_2 $$2MeSH$$aPresynaptic Terminals: ultrastructure
000285038 7001_ $$0P:(DE-2719)2810725$$aSchmitz, Dietmar$$b1$$udzne
000285038 7001_ $$00000-0002-9017-0251$$aOrlando, Marta$$b2
000285038 773__ $$0PERI:(DE-600)1500673-6$$a10.1016/j.pneurobio.2026.102882$$gVol. 258, p. 102882 -$$p102882$$tProgress in neurobiology$$v258$$x0301-0082$$y2026
000285038 8564_ $$uhttps://pub.dzne.de/record/285038/files/DZNE-2026-00162%20SUP.pdf
000285038 8564_ $$uhttps://pub.dzne.de/record/285038/files/DZNE-2026-00162%20SUP.pdf?subformat=pdfa$$xpdfa
000285038 8564_ $$uhttps://pub.dzne.de/record/285038/files/DZNE-2026-00162.pdf$$yOpenAccess
000285038 8564_ $$uhttps://pub.dzne.de/record/285038/files/DZNE-2026-00162.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000285038 909CO $$ooai:pub.dzne.de:285038$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000285038 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810725$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000285038 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000285038 9141_ $$y2026
000285038 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000285038 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000285038 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2025-11-12$$wger
000285038 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPROG NEUROBIOL : 2022$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)1120$$2StatID$$aDBCoverage$$bBIOSIS Reviews Reports And Meetings$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-11-12
000285038 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bPROG NEUROBIOL : 2022$$d2025-11-12
000285038 9201_ $$0I:(DE-2719)1810004$$kAG Schmitz$$lNetwork Dysfunction$$x0
000285038 980__ $$ajournal
000285038 980__ $$aVDB
000285038 980__ $$aI:(DE-2719)1810004
000285038 980__ $$aUNRESTRICTED
000285038 9801_ $$aFullTexts