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@ARTICLE{Bruentgens:285038,
      author       = {Bruentgens, Felicitas and Schmitz, Dietmar and Orlando,
                      Marta},
      title        = {{T}he flexible synapse – {H}ow mossy fiber architecture
                      adapts to changing needs},
      journal      = {Progress in neurobiology},
      volume       = {258},
      issn         = {0301-0082},
      address      = {Jena},
      publisher    = {Elsevier},
      reportid     = {DZNE-2026-00162},
      pages        = {102882},
      year         = {2026},
      abstract     = {Hippocampal mossy fiber boutons are unique, highly plastic
                      synapses within the hippocampal circuitry. Despite mossy
                      fiber bouton's potential role in learning and memory
                      processes, the precise underlying mechanisms leading to
                      their strengthened synaptic connections are still not fully
                      understood. Here, we provide an overview of the structural
                      changes occurring during long-term potentiation of large
                      presynaptic terminals formed by mossy fiber onto CA3
                      pyramidal cells. Such changes encompass (1) adaptations in
                      the number, shape and size of the bouton; (2) changes in
                      availability of synaptic vesicles as well as the number and
                      occupancy of release sites within single boutons; and (3)
                      nano-architectural changes in the molecular composition and
                      spatial arrangements within active zones. We describe these
                      changes and possible implications for mossy fiber function.
                      Furthermore, we discuss open questions, current methodology,
                      and possible future directions.},
      subtyp        = {Review Article},
      cin          = {AG Schmitz},
      ddc          = {610},
      cid          = {I:(DE-2719)1810004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.pneurobio.2026.102882},
      url          = {https://pub.dzne.de/record/285038},
}