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001     285038
005     20260309111159.0
024 7 _ |a 10.1016/j.pneurobio.2026.102882
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024 7 _ |a 1873-5118
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037 _ _ |a DZNE-2026-00162
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Bruentgens, Felicitas
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245 _ _ |a The flexible synapse – How mossy fiber architecture adapts to changing needs
260 _ _ |a Jena
|c 2026
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520 _ _ |a Hippocampal mossy fiber boutons are unique, highly plastic synapses within the hippocampal circuitry. Despite mossy fiber bouton's potential role in learning and memory processes, the precise underlying mechanisms leading to their strengthened synaptic connections are still not fully understood. Here, we provide an overview of the structural changes occurring during long-term potentiation of large presynaptic terminals formed by mossy fiber onto CA3 pyramidal cells. Such changes encompass (1) adaptations in the number, shape and size of the bouton; (2) changes in availability of synaptic vesicles as well as the number and occupancy of release sites within single boutons; and (3) nano-architectural changes in the molecular composition and spatial arrangements within active zones. We describe these changes and possible implications for mossy fiber function. Furthermore, we discuss open questions, current methodology, and possible future directions.
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650 _ 7 |a Hippocampus
|2 Other
650 _ 7 |a LTP
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650 _ 7 |a Mossy fibers
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650 _ 7 |a Presynaptic terminals
|2 Other
650 _ 7 |a Structural plasticity
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650 _ 7 |a Synaptic plasticity
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650 _ 2 |a Mossy Fibers, Hippocampal: physiology
|2 MeSH
650 _ 2 |a Mossy Fibers, Hippocampal: ultrastructure
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Synapses: physiology
|2 MeSH
650 _ 2 |a Synapses: ultrastructure
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
650 _ 2 |a Long-Term Potentiation: physiology
|2 MeSH
650 _ 2 |a Presynaptic Terminals: physiology
|2 MeSH
650 _ 2 |a Presynaptic Terminals: ultrastructure
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700 1 _ |a Schmitz, Dietmar
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700 1 _ |a Orlando, Marta
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773 _ _ |a 10.1016/j.pneurobio.2026.102882
|g Vol. 258, p. 102882 -
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|t Progress in neurobiology
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856 4 _ |u https://pub.dzne.de/record/285038/files/DZNE-2026-00162%20SUP.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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