TY  - JOUR
AU  - Palleis, Carla
AU  - Bernhardt, Alexander Maximilian
AU  - Weidinger, Endy
AU  - Fietzek, Urban M
AU  - Jäck, Alexander
AU  - Katzdobler, Sabrina
AU  - Gnoerich, Johannes
AU  - Bauer, Theresa
AU  - Franzmeier, Nicolai
AU  - Perneczky, Robert
AU  - Brendel, Matthias
AU  - Levin, Johannes
AU  - Höglinger, Günter U
TI  - A Biomarker-Based Classification of Corticobasal Syndrome.
JO  - Movement disorders
VL  - 41
IS  - 1
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2026-00167
SP  - 129 - 142
PY  - 2026
AB  - Corticobasal syndrome (CBS) is a clinically defined syndrome with progressive movement and cortical dysfunction, caused by various underlying pathologies, most commonly tau-predominant pathologies such as progressive supranuclear palsy and corticobasal degeneration, or Alzheimer's disease (AD). Lewy-type α-synucleinopathies (LTS), TDP-43 proteinopathies, and mixed pathologies may also underlie CBS. The clinical impact of these pathologies remains poorly understood.To subclassify CBS patients in vivo using biomarkers for amyloid-β (Aβ), Tau, and α-synuclein (αSyn), and assess the clinical relevance of this stratification.We conducted a prospective cohort study of 50 CBS patients at LMU University Hospital Munich. Biomarker analysis included cerebrospinal fluid (CSF) Aβ42 and Aβ42/40, [18F]flutemetamol Aβ-PET, [18F]PI-2620 tau-PET, and αSyn seed amplification assays in CSF. CSF neurofilament light chain (NfL) served as a marker of neurodegeneration. Patients were stratified into six groups based on biomarker positivity.Tau positivity was found in 90
KW  - Humans
KW  - Male
KW  - Female
KW  - Aged
KW  - Biomarkers: cerebrospinal fluid
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Middle Aged
KW  - tau Proteins: cerebrospinal fluid
KW  - Positron-Emission Tomography
KW  - alpha-Synuclein: cerebrospinal fluid
KW  - alpha-Synuclein: metabolism
KW  - Prospective Studies
KW  - Corticobasal Degeneration: classification
KW  - Corticobasal Degeneration: cerebrospinal fluid
KW  - Corticobasal Degeneration: diagnostic imaging
KW  - Peptide Fragments: cerebrospinal fluid
KW  - Aged, 80 and over
KW  - proteinopathies (Other)
KW  - tau‐PET (Other)
KW  - α‐synuclein seed amplification assay (Other)
KW  - β‐amyloid (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - alpha-Synuclein (NLM Chemicals)
KW  - Peptide Fragments (NLM Chemicals)
KW  - amyloid beta-protein (1-42) (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41048081
C2  - pmc:PMC12882055
DO  - DOI:10.1002/mds.70070
UR  - https://pub.dzne.de/record/285043
ER  -