TY  - JOUR
AU  - Lischewski, Stella Andrea
AU  - Dogan, Imis
AU  - Giunti, Paola
AU  - Parkinson, Michael H
AU  - Mariotti, Caterina
AU  - Durr, Alexandra
AU  - Ewenczyk, Claire
AU  - Boesch, Sylvia
AU  - Nachbauer, Wolfgang
AU  - Klopstock, Thomas
AU  - Stendel, Claudia
AU  - de Rivera Garrido, Francisco Javier Rodríguez
AU  - Schöls, Ludger
AU  - Fleszar, Zofia
AU  - Klockgether, Thomas
AU  - Grobe-Einsler, Marcus
AU  - Giordano, Ilaria
AU  - Rai, Myriam
AU  - Pandolfo, Massimo
AU  - Jacobi, Heike
AU  - Hilgers, Ralf-Dieter
AU  - Schulz, Jörg B
AU  - Reetz, Kathrin
TI  - Analysis of a Modified Version of the Inventory of Non-Ataxia Signs Over 12 Years in Patients with Friedreich's Ataxia in the EFACTS Study.
JO  - Movement disorders
VL  - 41
IS  - 1
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2026-00168
SP  - 200 - 211
PY  - 2026
AB  - Friedreich's ataxia is a rare, neurodegenerative, multisystem disorder. While ataxia is a hallmark, non-ataxia signs, including muscle weakness, spasticity, and dysphagia are equally disabling. The Inventory of Non-Ataxia Signs (INAS) is a symptom list transformable to a 16-item count.To evaluate the responsiveness of a modified INAS in this population.Participants were drawn from the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS). The modified INAS count (presence/absence, 0-16 scale) and modified INAS sum (severity-weighted, 0-84 scale) were evaluated using linear mixed-models and standardized response means (SRMs). Items rare (<5
KW  - Humans
KW  - Friedreich Ataxia: diagnosis
KW  - Friedreich Ataxia: physiopathology
KW  - Friedreich Ataxia: complications
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Aged
KW  - Young Adult
KW  - Severity of Illness Index
KW  - Adolescent
KW  - Child
KW  - Friedreich's ataxia (Other)
KW  - longitudinal (Other)
KW  - non‐ataxia symptoms (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41070559
C2  - pmc:PMC12882042
DO  - DOI:10.1002/mds.70084
UR  - https://pub.dzne.de/record/285044
ER  -