TY  - JOUR
AU  - Völker, Lotta
AU  - Müller-Jensen, Leonie
AU  - Carl, Sophia
AU  - Nay, Sandra
AU  - Möllenkamp, Thiemo Malte
AU  - Schultze-Florey, Christian
AU  - Grote-Levi, Lea
AU  - Jendretzky, Konstantin F
AU  - Konen, Franz Felix
AU  - Könecke, Christian
AU  - Eder, Matthias
AU  - Panagiota, Victoria
AU  - Heidel, Florian H
AU  - Bullinger, Lars
AU  - Damm, Frederik
AU  - Frick, Mareike
AU  - Penack, Olaf
AU  - Ludwig, Rebecca
AU  - Buß, Eric Anil
AU  - Boehmerle, Wolfgang
AU  - Endres, Matthias
AU  - Gudi, Viktoria
AU  - Huehnchen, Petra
AU  - Skripuletz, Thomas
AU  - Möhn, Nora
TI  - The Berlin-Hannover ICANS severity assessment-a novel bedside test to evaluate CAR T-cell-associated neurotoxicity.
JO  - Frontiers in neurology
VL  - 17
SN  - 1664-2295
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2026-00176
SP  - 1726779
PY  - 2026
AB  - Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of refractory hematological malignancies but is frequently complicated by immune effector cell-associated neurotoxicity syndrome (ICANS). Early clinical recognition remains challenging, as the commonly used Immune Effector Cell-Associated Encephalopathy (ICE) score lacks sensitivity for subtle deficits.In this prospective bicentric study, 100 patients treated with CAR T-cells at Hannover Medical School and Charité - Universitätsmedizin Berlin underwent systematic neurological assessments using both ICE and the newly developed Berlin-Hannover ICANS Severity Assessment (BHISA). Examinations were performed at baseline prior to CAR T-cell infusion, on day 6-7 (±1 day) post-infusion, and during ICANS episodes. Data on the clinical course, other toxicities, comorbidities, CAR T-cell products, and ICANS treatment were collected.Thirty-seven patients (37
KW  - BHISA (Other)
KW  - CAR T-cell therapy (Other)
KW  - ICANS (Other)
KW  - ICE (Other)
KW  - screening tools (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41648666
C2  - pmc:PMC12867840
DO  - DOI:10.3389/fneur.2026.1726779
UR  - https://pub.dzne.de/record/285052
ER  -