%0 Journal Article
%A Saadmaan, Gazi
%A Dalmasso, Maria Carolina
%A Maria, Maleeha
%A Lehtisalo, Jenni
%A Hiltunen, Mikko
%A Kaikkonen, Minna U
%A Levälahti, Esko
%A Mangialasche, Francesca
%A Perola, Markus
%A Ramirez, Alfredo
%A Stephen, Ruth
%A Ngandu, Tiia
%A Kivipelto, Miia
%A Solomon, Alina
%T Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial.
%J Brain
%V 149
%N 2
%@ 0006-8950
%C Oxford
%I Oxford Univ. Press
%M DZNE-2026-00177
%P 644 - 652
%D 2026
%X Alzheimer's disease and coronary artery disease are common late-life chronic conditions and share multiple risk factors, including the apolipoprotein E (APOE) ε4 allele. A meta-analysis of two multidomain lifestyle intervention trials found greater cognitive benefits in APOE4 carriers compared with non-carriers. This study investigated the impact of genetic risk scores for Alzheimer's disease and coronary artery disease (AD-GRS, CAD-GRS) on cognition in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomized controlled trial. FINGER included 1259 at-risk individuals without dementia from the general population, aged 60-77 years. Participants were randomized 1:1 to a 2-year multidomain lifestyle intervention or regular health advice. The primary outcome was change in cognition based on a modified Neuropsychological Test Battery (14 tests). Previous comprehensive AD-GRS and CAD-GRS were calculated using genome-wide association study data (1177 participants, with 585 in the control and 592 in the intervention groups, exploratory analysis). The intervention-control difference in annual overall cognition change (95
%K Humans
%K Male
%K Female
%K Aged
%K Middle Aged
%K Alzheimer Disease: genetics
%K Alzheimer Disease: psychology
%K Cognition: physiology
%K Neuropsychological Tests
%K Coronary Artery Disease: genetics
%K Coronary Artery Disease: psychology
%K Apolipoprotein E4: genetics
%K Genetic Predisposition to Disease
%K Genome-Wide Association Study
%K Cognitive Dysfunction: genetics
%K Risk Factors
%K Finland
%K Life Style
%K Alzheimer’s disease (Other)
%K cognition (Other)
%K genetic risk scores (Other)
%K multidomain intervention (Other)
%K randomized controlled trial (Other)
%K Apolipoprotein E4 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40747850
%R 10.1093/brain/awaf277
%U https://pub.dzne.de/record/285053