TY  - JOUR
AU  - Saadmaan, Gazi
AU  - Dalmasso, Maria Carolina
AU  - Maria, Maleeha
AU  - Lehtisalo, Jenni
AU  - Hiltunen, Mikko
AU  - Kaikkonen, Minna U
AU  - Levälahti, Esko
AU  - Mangialasche, Francesca
AU  - Perola, Markus
AU  - Ramirez, Alfredo
AU  - Stephen, Ruth
AU  - Ngandu, Tiia
AU  - Kivipelto, Miia
AU  - Solomon, Alina
TI  - Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial.
JO  - Brain
VL  - 149
IS  - 2
SN  - 0006-8950
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2026-00177
SP  - 644 - 652
PY  - 2026
AB  - Alzheimer's disease and coronary artery disease are common late-life chronic conditions and share multiple risk factors, including the apolipoprotein E (APOE) ε4 allele. A meta-analysis of two multidomain lifestyle intervention trials found greater cognitive benefits in APOE4 carriers compared with non-carriers. This study investigated the impact of genetic risk scores for Alzheimer's disease and coronary artery disease (AD-GRS, CAD-GRS) on cognition in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomized controlled trial. FINGER included 1259 at-risk individuals without dementia from the general population, aged 60-77 years. Participants were randomized 1:1 to a 2-year multidomain lifestyle intervention or regular health advice. The primary outcome was change in cognition based on a modified Neuropsychological Test Battery (14 tests). Previous comprehensive AD-GRS and CAD-GRS were calculated using genome-wide association study data (1177 participants, with 585 in the control and 592 in the intervention groups, exploratory analysis). The intervention-control difference in annual overall cognition change (95
KW  - Humans
KW  - Male
KW  - Female
KW  - Aged
KW  - Middle Aged
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: psychology
KW  - Cognition: physiology
KW  - Neuropsychological Tests
KW  - Coronary Artery Disease: genetics
KW  - Coronary Artery Disease: psychology
KW  - Apolipoprotein E4: genetics
KW  - Genetic Predisposition to Disease
KW  - Genome-Wide Association Study
KW  - Cognitive Dysfunction: genetics
KW  - Risk Factors
KW  - Finland
KW  - Life Style
KW  - Alzheimer’s disease (Other)
KW  - cognition (Other)
KW  - genetic risk scores (Other)
KW  - multidomain intervention (Other)
KW  - randomized controlled trial (Other)
KW  - Apolipoprotein E4 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40747850
DO  - DOI:10.1093/brain/awaf277
UR  - https://pub.dzne.de/record/285053
ER  -