000285054 001__ 285054
000285054 005__ 20260209111009.0
000285054 037__ $$aDZNE-2026-00178
000285054 1001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b0$$udzne
000285054 245__ $$aDataset: Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice
000285054 260__ $$bGene Expression Omnibus$$c2026
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000285054 520__ $$aAging is a key risk factor for disease in mammals, yet its molecular basis across organs remains unclear. Here, we performed bulk RNA sequencing on eight organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen, testis) from male C57BL/6J mice at distinct life stages. Our analysis revealed that age-related transcriptomic shifts vary in timing and magnitude: early in lung, spleen, testis; mid-life in heart, kidney, skeletal muscle; and late in brain and liver. Magnitude ranged from very low (testis), low (brain, heart), moderate (lungs, skeletal muscle) to high (kidneys, liver, spleen). We uncovered organ-specific aging signatures, for instance, mitochondrial and epigenetic regulation in the kidney, metabolic/detoxification in the lung, and angiogenesis as well as ribosome biogenesis in the spleen). We also identified shared transcriptomic signatures, such as cellular senescence in the kidney and skeletal muscle, ECM remodeling in the heart, skeletal muscle and spleen), or inflammation in the heart, kidney, liver and lungs. These findings highlight unique and overlapping transcriptomic aging signatures, informing future therapeutic strategies to improve healthspan.
000285054 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000285054 7001_ $$0P:(DE-2719)2812562$$aScifo, Enzo$$b1$$udzne
000285054 7001_ $$0P:(DE-2719)9002881$$aMorsy, Sarah$$b2$$udzne
000285054 7870_ $$0DZNE-2026-00049$$aMorsy, Sarah et.al.$$dOxford [u.a.] : Wiley-Blackwell, 2026$$iRelatedTo$$r$$tDeciphering the Transcriptomic Signatures of Aging Across Organs in Mice
000285054 8564_ $$uhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291420
000285054 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2289209$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000285054 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812562$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000285054 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002881$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000285054 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000285054 9201_ $$0I:(DE-2719)1013005$$kAG Ehninger$$lTranslational Biogerontology$$x0
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000285054 980__ $$aEDITORS
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000285054 980__ $$aI:(DE-2719)1013005
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