guest ::
| Home > Publications Database > Advancing CNS tumor diagnostics with expanded DNA methylation-based classification. > print |
| Home > Publications Database > Advancing CNS tumor diagnostics with expanded DNA methylation-based classification. > print |
| 001 | 285055 | ||
| 005 | 20260304110135.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2025.11.002 |2 doi |
| 024 | 7 | _ | |a pmid:41349541 |2 pmid |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 037 | _ | _ | |a DZNE-2026-00179 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Sill, Martin |b 0 |
| 245 | _ | _ | |a Advancing CNS tumor diagnostics with expanded DNA methylation-based classification. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2026 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1772534521_20773 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization (WHO) classification of central nervous system (CNS) tumors. We present the Heidelberg CNS Tumor Methylation Classifier version 12.8 (v12.8), trained on 7,495 methylation profiles, which expands recognized entities from 91 classes in version 11 (v11) to 184 subclasses. This expansion is a result of newly identified tumor types discovered through our large online repository and global collaborations, underscoring CNS tumor heterogeneity. The random forest-based classifier achieves 95% subclass-level accuracy, with its well-calibrated probabilistic scores providing a reliable measure of confidence for each classification. Its hierarchical output structure enables interpretation across subclass, class, family, and superfamily levels, thereby supporting clinical decisions at multiple granularities. Comparative analyses demonstrate that v12.8 surpasses previous versions and conventional WHO-based approaches. These advances highlight the improved precision and practical utility of the updated classifier in personalized neuro-oncology. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a CNS tumors |2 Other |
| 650 | _ | 7 | |a DNA methylation |2 Other |
| 650 | _ | 7 | |a MLOps |2 Other |
| 650 | _ | 7 | |a artificial intelligence |2 Other |
| 650 | _ | 7 | |a classification |2 Other |
| 650 | _ | 7 | |a epigenetics |2 Other |
| 650 | _ | 7 | |a machine learning |2 Other |
| 650 | _ | 7 | |a molecular diagnostics |2 Other |
| 650 | _ | 7 | |a precision medicine |2 Other |
| 650 | _ | 7 | |a tumor heterogeneity |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a DNA Methylation |2 MeSH |
| 650 | _ | 2 | |a Central Nervous System Neoplasms: genetics |2 MeSH |
| 650 | _ | 2 | |a Central Nervous System Neoplasms: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Central Nervous System Neoplasms: classification |2 MeSH |
| 650 | _ | 2 | |a Biomarkers, Tumor: genetics |2 MeSH |
| 700 | 1 | _ | |a Schrimpf, Daniel |b 1 |
| 700 | 1 | _ | |a Patel, Areeba |b 2 |
| 700 | 1 | _ | |a Sturm, Dominik |b 3 |
| 700 | 1 | _ | |a Jäger, Natalie |b 4 |
| 700 | 1 | _ | |a Sievers, Philipp |b 5 |
| 700 | 1 | _ | |a Schweizer, Leonille |b 6 |
| 700 | 1 | _ | |a Banan, Rouzbeh |b 7 |
| 700 | 1 | _ | |a Reuss, David |b 8 |
| 700 | 1 | _ | |a Suwala, Abigail |b 9 |
| 700 | 1 | _ | |a Korshunov, Andrey |b 10 |
| 700 | 1 | _ | |a Stichel, Damian |b 11 |
| 700 | 1 | _ | |a Wefers, Annika K |b 12 |
| 700 | 1 | _ | |a Hau, Ann-Christin |b 13 |
| 700 | 1 | _ | |a Boldt, Henning |b 14 |
| 700 | 1 | _ | |a Harter, Patrick N |b 15 |
| 700 | 1 | _ | |a Abdullaev, Zied |b 16 |
| 700 | 1 | _ | |a Benhamida, Jamal |b 17 |
| 700 | 1 | _ | |a Teichmann, Daniel |b 18 |
| 700 | 1 | _ | |a Koch, Arend |b 19 |
| 700 | 1 | _ | |a Hench, Jürgen |b 20 |
| 700 | 1 | _ | |a Frank, Stephan |b 21 |
| 700 | 1 | _ | |a Hasselblatt, Martin |b 22 |
| 700 | 1 | _ | |a Mansouri, Sheila |b 23 |
| 700 | 1 | _ | |a Díaz de Ståhl, Theresita |b 24 |
| 700 | 1 | _ | |a Serrano, Jonathan |b 25 |
| 700 | 1 | _ | |a Ecker, Jonas |b 26 |
| 700 | 1 | _ | |a Selt, Florian |b 27 |
| 700 | 1 | _ | |a Taylor, Michael |b 28 |
| 700 | 1 | _ | |a Ramaswamy, Vijay |b 29 |
| 700 | 1 | _ | |a Cavalli, Florence |b 30 |
| 700 | 1 | _ | |a Berghoff, Anna S |b 31 |
| 700 | 1 | _ | |a Bison, Brigitte |b 32 |
| 700 | 1 | _ | |a Blattner-Johnson, Mirjam |b 33 |
| 700 | 1 | _ | |a Buchhalter, Ivo |b 34 |
| 700 | 1 | _ | |a Buslei, Rolf |b 35 |
| 700 | 1 | _ | |a Calaminus, Gabriele |b 36 |
| 700 | 1 | _ | |a Dikow, Nicola |b 37 |
| 700 | 1 | _ | |a Dohmen, Hildegard |b 38 |
| 700 | 1 | _ | |a Euskirchen, Philipp |b 39 |
| 700 | 1 | _ | |a Fleischhack, Gudrun |b 40 |
| 700 | 1 | _ | |a Gajjar, Amar |b 41 |
| 700 | 1 | _ | |a Gerber, Nicolas U |b 42 |
| 700 | 1 | _ | |a Gessi, Marco |b 43 |
| 700 | 1 | _ | |a Gielen, Gerrit H |b 44 |
| 700 | 1 | _ | |a Gnekow, Astrid |b 45 |
| 700 | 1 | _ | |a Gottardo, Nicholas G |b 46 |
| 700 | 1 | _ | |a Haberler, Christine |b 47 |
| 700 | 1 | _ | |a Hamelmann, Stefan |b 48 |
| 700 | 1 | _ | |a Hans, Volkmar |b 49 |
| 700 | 1 | _ | |a Hansford, Jordan R |b 50 |
| 700 | 1 | _ | |a Hartmann, Christian |b 51 |
| 700 | 1 | _ | |a Heppner, Frank L |0 P:(DE-2719)2812386 |b 52 |u dzne |
| 700 | 1 | _ | |a Driever, Pablo Hernaiz |b 53 |
| 700 | 1 | _ | |a von Hoff, Katja |b 54 |
| 700 | 1 | _ | |a Thomale, Ulrich W |b 55 |
| 700 | 1 | _ | |a Tippelt, Stephan |b 56 |
| 700 | 1 | _ | |a Frühwald, Michael C |b 57 |
| 700 | 1 | _ | |a Kramm, Christof M |b 58 |
| 700 | 1 | _ | |a Schüller, Ulrich |b 59 |
| 700 | 1 | _ | |a Schittenhelm, Jens |b 60 |
| 700 | 1 | _ | |a Schuhmann, Martin U |b 61 |
| 700 | 1 | _ | |a Stein, Marco |b 62 |
| 700 | 1 | _ | |a Ketteler, Petra |b 63 |
| 700 | 1 | _ | |a Ladanyi, Marc |b 64 |
| 700 | 1 | _ | |a Jabado, Nada |b 65 |
| 700 | 1 | _ | |a Jones, Barbara C |b 66 |
| 700 | 1 | _ | |a Jones, Chris |b 67 |
| 700 | 1 | _ | |a Karajannis, Matthias A |b 68 |
| 700 | 1 | _ | |a Ketter, Ralf |b 69 |
| 700 | 1 | _ | |a Kohlhof, Patricia |b 70 |
| 700 | 1 | _ | |a Kordes, Uwe |b 71 |
| 700 | 1 | _ | |a Reinhardt, Annekathrin |b 72 |
| 700 | 1 | _ | |a Kölsche, Christian |b 73 |
| 700 | 1 | _ | |a Lamszus, Katrin |b 74 |
| 700 | 1 | _ | |a Lichter, Peter |b 75 |
| 700 | 1 | _ | |a Maas, Sybren L N |b 76 |
| 700 | 1 | _ | |a Mawrin, Christian |b 77 |
| 700 | 1 | _ | |a Milde, Till |b 78 |
| 700 | 1 | _ | |a Mittelbronn, Michel |b 79 |
| 700 | 1 | _ | |a Monoranu, Camelia-Maria |b 80 |
| 700 | 1 | _ | |a Mueller, Wolf |b 81 |
| 700 | 1 | _ | |a Mynarek, Martin |b 82 |
| 700 | 1 | _ | |a Northcott, Paul A |b 83 |
| 700 | 1 | _ | |a Pajtler, Kristian W |b 84 |
| 700 | 1 | _ | |a Paulus, Werner |b 85 |
| 700 | 1 | _ | |a Perry, Arie |b 86 |
| 700 | 1 | _ | |a Blümcke, Ingmar |b 87 |
| 700 | 1 | _ | |a Plate, Karl H |b 88 |
| 700 | 1 | _ | |a Platten, Michael |b 89 |
| 700 | 1 | _ | |a Preusser, Matthias |b 90 |
| 700 | 1 | _ | |a Pietsch, Torsten |0 P:(DE-2719)2812617 |b 91 |u dzne |
| 700 | 1 | _ | |a Prinz, Marco |b 92 |
| 700 | 1 | _ | |a Reifenberger, Guido |b 93 |
| 700 | 1 | _ | |a Kristensen, Bjarne W |b 94 |
| 700 | 1 | _ | |a Kool, Marcel |b 95 |
| 700 | 1 | _ | |a Hovestadt, Volker |b 96 |
| 700 | 1 | _ | |a Ellison, David W |b 97 |
| 700 | 1 | _ | |a Jacques, Thomas S |b 98 |
| 700 | 1 | _ | |a Varlet, Pascale |b 99 |
| 700 | 1 | _ | |a Etminan, Nima |b 100 |
| 700 | 1 | _ | |a Acker, Till |b 101 |
| 700 | 1 | _ | |a Weller, Michael |b 102 |
| 700 | 1 | _ | |a White, Christine L |b 103 |
| 700 | 1 | _ | |a Witt, Olaf |b 104 |
| 700 | 1 | _ | |a Herold-Mende, Christel |b 105 |
| 700 | 1 | _ | |a Debus, Jürgen |b 106 |
| 700 | 1 | _ | |a Krieg, Sandro |b 107 |
| 700 | 1 | _ | |a Wick, Wolfgang |b 108 |
| 700 | 1 | _ | |a Snuderl, Matija |b 109 |
| 700 | 1 | _ | |a Aldape, Ken |b 110 |
| 700 | 1 | _ | |a Brandner, Sebastian |b 111 |
| 700 | 1 | _ | |a Hawkins, Cynthia |b 112 |
| 700 | 1 | _ | |a Horbinski, Craig |b 113 |
| 700 | 1 | _ | |a Thomas, Christian |b 114 |
| 700 | 1 | _ | |a Wesseling, Pieter |b 115 |
| 700 | 1 | _ | |a von Deimling, Andreas |b 116 |
| 700 | 1 | _ | |a Capper, David |b 117 |
| 700 | 1 | _ | |a Pfister, Stefan M |b 118 |
| 700 | 1 | _ | |a Jones, David T W |b 119 |
| 700 | 1 | _ | |a Sahm, Felix |b 120 |
| 773 | _ | _ | |a 10.1016/j.ccell.2025.11.002 |g p. S1535610825004957 |0 PERI:(DE-600)2074034-7 |n 2 |p 340 - 354.e2 |t Cancer cell |v 44 |y 2026 |x 1535-6108 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/285055/files/DZNE-2026-00179%20SUP.zip |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/285055/files/DZNE-2026-00179.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/285055/files/DZNE-2026-00179.pdf?subformat=pdfa |
| 909 | C | O | |o oai:pub.dzne.de:285055 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 52 |6 P:(DE-2719)2812386 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 91 |6 P:(DE-2719)2812617 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 914 | 1 | _ | |y 2026 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2024-12-20 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b CANCER CELL : 2022 |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2024-12-20 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2024-12-20 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2024-12-20 |
| 915 | _ | _ | |a IF >= 50 |0 StatID:(DE-HGF)9950 |2 StatID |b CANCER CELL : 2022 |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2024-12-20 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2024-12-20 |
| 920 | 1 | _ | |0 I:(DE-2719)1810007 |k AG Heppner |l Neuroimmunology |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1810007 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|