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000285159 1001_ $$0P:(DE-2719)2814194$$aHermann, Wiebke$$b0$$udzne
000285159 245__ $$aGait dysfunction as an early marker of phenoconversion in REM sleep behavior disorder.
000285159 260__ $$a[London]$$bSpringer Nature$$c2026
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000285159 520__ $$aClinical isolated REM Sleep Behavior Disorder (iRBD) is a prodromal stage of α-synucleinopathies such as Parkinson's disease (PD). Longitudinal changes of gait as a marker of phenoconversion in iRBD have not been systematically evaluated yet. Therefore, twenty-one iRBD patients, nineteen matched healthy controls and fourteen PD patients (H&Y stage I - III) were assessed at baseline using a pressure-sensor walkway (GAITRite). While normalized gait velocity and walking endurance were significantly decreased in iRBD patients compared to controls, gait rhythm parameters such as single support further discriminated PD from iRBD and controls. IRBD patients at imminent risk of phenoconversion within the next 3.7 ± 0.6 years were distinguishable from non-converters by gait rhythm parameters such as single support. Since gait evaluation of our iRBD cohort showed promising results in predicting imminent phenoconversion, future multicenter trials should include gait analysis as an objective assessment of motor function to confirm our results.
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000285159 650_7 $$2Other$$aGait dysfunction
000285159 650_7 $$2Other$$aParkinson’s disease
000285159 650_7 $$2Other$$aProgression
000285159 650_7 $$2Other$$aREM sleep behaviour disorder
000285159 650_7 $$2Other$$aΑ-synucleinopathies
000285159 650_7 $$2NLM Chemicals$$aBiomarkers
000285159 650_2 $$2MeSH$$aHumans
000285159 650_2 $$2MeSH$$aREM Sleep Behavior Disorder: physiopathology
000285159 650_2 $$2MeSH$$aREM Sleep Behavior Disorder: diagnosis
000285159 650_2 $$2MeSH$$aMale
000285159 650_2 $$2MeSH$$aFemale
000285159 650_2 $$2MeSH$$aMiddle Aged
000285159 650_2 $$2MeSH$$aParkinson Disease: physiopathology
000285159 650_2 $$2MeSH$$aParkinson Disease: diagnosis
000285159 650_2 $$2MeSH$$aAged
000285159 650_2 $$2MeSH$$aGait: physiology
000285159 650_2 $$2MeSH$$aCase-Control Studies
000285159 650_2 $$2MeSH$$aBiomarkers
000285159 650_2 $$2MeSH$$aGait Disorders, Neurologic: physiopathology
000285159 650_2 $$2MeSH$$aGait Disorders, Neurologic: diagnosis
000285159 7001_ $$aSankutlu, Aleyna$$b1
000285159 7001_ $$aNabers, Lydia$$b2
000285159 7001_ $$aSehr, Tony$$b3
000285159 7001_ $$aTrentzsch, Katrin$$b4
000285159 7001_ $$0P:(DE-2719)2501739$$aDonix, Markus$$b5$$udzne
000285159 7001_ $$aReichmann, Heinz$$b6
000285159 7001_ $$0P:(DE-2719)2812107$$aBrandt, Daniel Moritz$$b7$$udzne
000285159 7001_ $$0P:(DE-2719)9000306$$aStorch, Alexander$$b8$$udzne
000285159 7001_ $$aZiemssen, Tjalf$$b9
000285159 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-026-37925-w$$gVol. 16, no. 1, p. 5614$$n1$$p5614$$tScientific reports$$v16$$x2045-2322$$y2026
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