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@ARTICLE{Hermann:285159,
      author       = {Hermann, Wiebke and Sankutlu, Aleyna and Nabers, Lydia and
                      Sehr, Tony and Trentzsch, Katrin and Donix, Markus and
                      Reichmann, Heinz and Brandt, Daniel Moritz and Storch,
                      Alexander and Ziemssen, Tjalf},
      title        = {{G}ait dysfunction as an early marker of phenoconversion in
                      {REM} sleep behavior disorder.},
      journal      = {Scientific reports},
      volume       = {16},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2026-00181},
      pages        = {5614},
      year         = {2026},
      abstract     = {Clinical isolated REM Sleep Behavior Disorder (iRBD) is a
                      prodromal stage of α-synucleinopathies such as Parkinson's
                      disease (PD). Longitudinal changes of gait as a marker of
                      phenoconversion in iRBD have not been systematically
                      evaluated yet. Therefore, twenty-one iRBD patients, nineteen
                      matched healthy controls and fourteen PD patients $(H\&Y$
                      stage I - III) were assessed at baseline using a
                      pressure-sensor walkway (GAITRite). While normalized gait
                      velocity and walking endurance were significantly decreased
                      in iRBD patients compared to controls, gait rhythm
                      parameters such as single support further discriminated PD
                      from iRBD and controls. IRBD patients at imminent risk of
                      phenoconversion within the next 3.7 ± 0.6 years were
                      distinguishable from non-converters by gait rhythm
                      parameters such as single support. Since gait evaluation of
                      our iRBD cohort showed promising results in predicting
                      imminent phenoconversion, future multicenter trials should
                      include gait analysis as an objective assessment of motor
                      function to confirm our results.},
      keywords     = {Humans / REM Sleep Behavior Disorder: physiopathology / REM
                      Sleep Behavior Disorder: diagnosis / Male / Female / Middle
                      Aged / Parkinson Disease: physiopathology / Parkinson
                      Disease: diagnosis / Aged / Gait: physiology / Case-Control
                      Studies / Biomarkers / Gait Disorders, Neurologic:
                      physiopathology / Gait Disorders, Neurologic: diagnosis /
                      Gait dysfunction (Other) / Parkinson’s disease (Other) /
                      Progression (Other) / REM sleep behaviour disorder (Other) /
                      Α-synucleinopathies (Other) / Biomarkers (NLM Chemicals)},
      cin          = {AG Storch},
      ddc          = {600},
      cid          = {I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41663457},
      doi          = {10.1038/s41598-026-37925-w},
      url          = {https://pub.dzne.de/record/285159},
}