%0 Journal Article
%A Halbgebauer, Rebecca
%A Gonzalez-Ortiz, Fernando
%A Mayer, Benjamin
%A Berger, Claudius
%A Bergmann, Christian
%A Rinderknecht, Helen
%A Barth, Eberhard
%A Wohlgemuth, Lisa
%A Mannes, Marco
%A Otto, Markus
%A Tumani, Hayrettin
%A Relja, Borna
%A Gebhard, Florian
%A Huber-Lang, Markus
%A Zetterberg, Henrik
%A Halbgebauer, Steffen
%A Blennow, Kaj
%T Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries.
%J JAMA network open
%V 9
%N 2
%@ 2574-3805
%C Chicago, Ill.
%I American Medical Association
%M DZNE-2026-00182
%P e2558573
%D 2026
%X With blood-based phosphorylated tau biomarkers soon to be used for diagnosis of Alzheimer disease, analyzing tau levels in other conditions could enhance biomarker interpretability. Moreover, mechanisms of tau release into circulation remain unclear.To evaluate concentrations of phosphorylated and nonphosphorylated tau variants in the blood of patients with multiple traumatic injuries on days 0, 1, 5, and 10 and investigate biological processes driving tau release.This multiple-trauma cohort (injury severity score, ≥18) included 45 severely injured patients with (n = 27) and without (n = 18) moderate-to-severe traumatic brain injury on emergency computed tomographic imaging. Controls consisted of 24 healthy volunteers. Participants were recruited from December 1, 2013, to October 31, 2022. Blood samples were analyzed for brain-derived tau (BD-tau), total tau (t-tau), and phosphorylated tau 217 (p-tau217) and 231 (p-tau231) levels. Associations among tau concentrations, clinical data, and outcome (eg, Glasgow Coma Scale [GCS] score) were assessed. Data were analyzed from March 1, 2023, to September 30, 2024.Serum BD-tau, t-tau, p-tau217, and p-tau231 levels.A total of 214 serum samples were analyzed. Median age of the 45 patients was 48 (IQR, 33-60) years (35 [77.8
%K Humans
%K tau Proteins: blood
%K Male
%K Female
%K Adult
%K Middle Aged
%K Biomarkers: blood
%K Brain Injuries, Traumatic: blood
%K Phosphorylation
%K Cohort Studies
%K Case-Control Studies
%K tau Proteins (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K MAPT protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41665901
%R 10.1001/jamanetworkopen.2025.58573
%U https://pub.dzne.de/record/285160