TY  - JOUR
AU  - Halbgebauer, Rebecca
AU  - Gonzalez-Ortiz, Fernando
AU  - Mayer, Benjamin
AU  - Berger, Claudius
AU  - Bergmann, Christian
AU  - Rinderknecht, Helen
AU  - Barth, Eberhard
AU  - Wohlgemuth, Lisa
AU  - Mannes, Marco
AU  - Otto, Markus
AU  - Tumani, Hayrettin
AU  - Relja, Borna
AU  - Gebhard, Florian
AU  - Huber-Lang, Markus
AU  - Zetterberg, Henrik
AU  - Halbgebauer, Steffen
AU  - Blennow, Kaj
TI  - Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries.
JO  - JAMA network open
VL  - 9
IS  - 2
SN  - 2574-3805
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DZNE-2026-00182
SP  - e2558573
PY  - 2026
AB  - With blood-based phosphorylated tau biomarkers soon to be used for diagnosis of Alzheimer disease, analyzing tau levels in other conditions could enhance biomarker interpretability. Moreover, mechanisms of tau release into circulation remain unclear.To evaluate concentrations of phosphorylated and nonphosphorylated tau variants in the blood of patients with multiple traumatic injuries on days 0, 1, 5, and 10 and investigate biological processes driving tau release.This multiple-trauma cohort (injury severity score, ≥18) included 45 severely injured patients with (n = 27) and without (n = 18) moderate-to-severe traumatic brain injury on emergency computed tomographic imaging. Controls consisted of 24 healthy volunteers. Participants were recruited from December 1, 2013, to October 31, 2022. Blood samples were analyzed for brain-derived tau (BD-tau), total tau (t-tau), and phosphorylated tau 217 (p-tau217) and 231 (p-tau231) levels. Associations among tau concentrations, clinical data, and outcome (eg, Glasgow Coma Scale [GCS] score) were assessed. Data were analyzed from March 1, 2023, to September 30, 2024.Serum BD-tau, t-tau, p-tau217, and p-tau231 levels.A total of 214 serum samples were analyzed. Median age of the 45 patients was 48 (IQR, 33-60) years (35 [77.8
KW  - Humans
KW  - tau Proteins: blood
KW  - Male
KW  - Female
KW  - Adult
KW  - Middle Aged
KW  - Biomarkers: blood
KW  - Brain Injuries, Traumatic: blood
KW  - Phosphorylation
KW  - Cohort Studies
KW  - Case-Control Studies
KW  - tau Proteins (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - MAPT protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41665901
DO  - DOI:10.1001/jamanetworkopen.2025.58573
UR  - https://pub.dzne.de/record/285160
ER  -