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@ARTICLE{Tong:285207,
      author       = {Tong, Benjamin Chun-Kit and Gubinelli, Francesco and
                      Burbulla, Lena F and Harbauer, Angelika B},
      title        = {{M}itochondrial specialization and signaling shape neuronal
                      function.},
      journal      = {Trends in neurosciences},
      volume       = {49},
      number       = {2},
      issn         = {0378-5912},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2026-00186},
      pages        = {141 - 154},
      year         = {2026},
      abstract     = {Neurons are specialized cells designed to process
                      information and transmit it, often across long distances. In
                      many neurons, the axonal volume far exceeds the
                      somato-dendritic volume, creating a need for long-range
                      transport and local polarization mechanisms. In addition,
                      action potential firing and restoration of ionic gradients,
                      as well as dynamic changes in synaptic plasticity, further
                      increase the energetic demands of neurons. In this review,
                      we highlight the roles mitochondria play in vertebrate
                      neuronal biology and how mitochondrial functionality is
                      tuned to support the unique demands of neurons. We cover the
                      influence of mitochondrial positioning, ATP generation and
                      Ca2+ buffering on neuronal function, and explore the role of
                      mitochondria in neurotransmitter metabolism and local
                      protein translation.},
      keywords     = {Mitochondria: physiology / Mitochondria: metabolism /
                      Animals / Neurons: physiology / Neurons: metabolism / Humans
                      / Signal Transduction: physiology / Neuronal Plasticity:
                      physiology / Calcium: metabolism / Ca(2+) signaling (Other)
                      / local translation (Other) / neuronal cell biology (Other)
                      / neurotransmitter metabolism (Other) / respiration (Other)
                      / transport (Other) / Calcium (NLM Chemicals)},
      cin          = {AG Burbulla},
      ddc          = {610},
      cid          = {I:(DE-2719)5000074},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41638946},
      doi          = {10.1016/j.tins.2025.12.006},
      url          = {https://pub.dzne.de/record/285207},
}