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024 7 _ |a 10.1016/j.tins.2025.12.006
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037 _ _ |a DZNE-2026-00186
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Tong, Benjamin Chun-Kit
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245 _ _ |a Mitochondrial specialization and signaling shape neuronal function.
260 _ _ |a Amsterdam [u.a.]
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520 _ _ |a Neurons are specialized cells designed to process information and transmit it, often across long distances. In many neurons, the axonal volume far exceeds the somato-dendritic volume, creating a need for long-range transport and local polarization mechanisms. In addition, action potential firing and restoration of ionic gradients, as well as dynamic changes in synaptic plasticity, further increase the energetic demands of neurons. In this review, we highlight the roles mitochondria play in vertebrate neuronal biology and how mitochondrial functionality is tuned to support the unique demands of neurons. We cover the influence of mitochondrial positioning, ATP generation and Ca2+ buffering on neuronal function, and explore the role of mitochondria in neurotransmitter metabolism and local protein translation.
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650 _ 7 |a Ca(2+) signaling
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650 _ 7 |a local translation
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650 _ 7 |a neuronal cell biology
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650 _ 7 |a neurotransmitter metabolism
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650 _ 7 |a respiration
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650 _ 7 |a transport
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650 _ 7 |a Calcium
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650 _ 2 |a Mitochondria: physiology
|2 MeSH
650 _ 2 |a Mitochondria: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Humans
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650 _ 2 |a Signal Transduction: physiology
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
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650 _ 2 |a Calcium: metabolism
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700 1 _ |a Gubinelli, Francesco
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700 1 _ |a Burbulla, Lena F
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700 1 _ |a Harbauer, Angelika B
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773 _ _ |a 10.1016/j.tins.2025.12.006
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