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000285250 1001_ $$aBahners, Bahne H$$b0
000285250 245__ $$aSpatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia.
000285250 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2026
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000285250 520__ $$aPallidal deep brain stimulation (DBS) has remarkable effects in patients with cervical dystonia. Yet, its neurophysiological mechanisms are not fully resolved to date. Converging evidence suggests that pallidal DBS modulates sensorimotor and cerebellar network activity in dystonia, possibly by disrupting pathologically enhanced low-frequency oscillations in the basal ganglia. Still, anatomical and electrophysiological findings have rarely been linked, and it is unclear whether oscillatory changes occur in the same network identified in neuroimaging studies.In this cross-sectional study, we investigate the effects of pallidal DBS in patients with cervical dystonia using magnetoencephalography recordings on and off stimulation. We correlated DBS outcomes to the whole-cortex pattern of DBS-induced power changes in each cortical vertex.This analysis revealed a distinct low-frequency electrophysiological signature that accounted for significant amounts of variance in DBS improvements across the cohort. The signature was characterised by negative peaks within the supplementary motor area and the motor cortex as well as positive peaks in prefrontal and cerebellar areas.Our study sheds light on the cortical and cerebellar effects of pallidal DBS on a whole-cortex level and puts emphasis on low-frequency power modulation as a mechanism of effective stimulation beyond the basal ganglia in patients with cervical dystonia. Our findings might inform DBS programming and targeting as well as non-invasive stimulation strategies in the future.Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)-Project-ID 424778381-TRR 295.
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000285250 650_7 $$2Other$$aBiomarker
000285250 650_7 $$2Other$$aElectrophysiology effect mapping
000285250 650_7 $$2Other$$aGlobus pallidus internus
000285250 650_7 $$2Other$$aMagnetoencephalography
000285250 650_7 $$2Other$$aNetwork mapping
000285250 650_2 $$2MeSH$$aHumans
000285250 650_2 $$2MeSH$$aTorticollis: therapy
000285250 650_2 $$2MeSH$$aTorticollis: physiopathology
000285250 650_2 $$2MeSH$$aTorticollis: diagnosis
000285250 650_2 $$2MeSH$$aTorticollis: etiology
000285250 650_2 $$2MeSH$$aDeep Brain Stimulation: methods
000285250 650_2 $$2MeSH$$aMale
000285250 650_2 $$2MeSH$$aFemale
000285250 650_2 $$2MeSH$$aGlobus Pallidus: physiopathology
000285250 650_2 $$2MeSH$$aMiddle Aged
000285250 650_2 $$2MeSH$$aMagnetoencephalography
000285250 650_2 $$2MeSH$$aAdult
000285250 650_2 $$2MeSH$$aTreatment Outcome
000285250 650_2 $$2MeSH$$aCross-Sectional Studies
000285250 650_2 $$2MeSH$$aAged
000285250 650_2 $$2MeSH$$aBrain Mapping
000285250 7001_ $$aLofredi, Roxanne$$b1
000285250 7001_ $$aVoss, Hannah$$b2
000285250 7001_ $$ade Almeida Marcelino, Ana Luísa$$b3
000285250 7001_ $$aGoede, Lukas L$$b4
000285250 7001_ $$aFeldmann, Lucia K$$b5
000285250 7001_ $$aSchnitzler, Alfons$$b6
000285250 7001_ $$aSander, Tilmann H$$b7
000285250 7001_ $$aFlorin, Esther$$b8
000285250 7001_ $$0P:(DE-2719)2811089$$aKühn, Andrea A$$b9$$eLast author$$udzne
000285250 773__ $$0PERI:(DE-600)2799017-5$$a10.1016/j.ebiom.2026.106140$$gVol. 124, p. 106140 -$$p106140$$tEBioMedicine$$v124$$x2352-3964$$y2026
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