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@ARTICLE{Wickel:285252,
      author       = {Wickel, Jonathan and Chung, Ha-Yeun and Konen, Franz Felix
                      and Rössling, Rosa and Bertolini, Annikki and Kraft, Andrea
                      and Siebenbrodt, Kai and Bittner, Stefan and Juranek,
                      Aleksandra and Brokbals, Mosche and Räuber, Saskia and
                      Klausewitz, Jaqueline and Pfeffer, Lena K and Scherag,
                      André and Menge, Til and Finke, Alexander and Doppler,
                      Kathrin and Urbanek, Christian and Bien, Christian G and
                      Seifert-Held, Thomas and Hoffmann, Frank and Wandinger,
                      Klaus-Peter and Tauber, Simone C and Süße, Marie and
                      Lewerenz, Jan and Madlener, Marie and Rostasy, Kevin and
                      Prüss, Harald and Sühs, Kurt-Wolfram and Kümpfel, Tania
                      and Thaler, Franziska S and Leypoldt, Frank and Geis,
                      Christian},
      collaboration = {group, GENERATE study},
      title        = {{R}educed {H}ospital {I}ncidence of {A}utoimmune
                      {E}ncephalitis {D}uring the {COVID}-19 {P}andemic.},
      journal      = {Neurology: Neuroimmunology $\&$ Neuroinflammation ;
                      official journal of the American Academy of Neurology},
      volume       = {13},
      number       = {3},
      issn         = {2332-7812},
      address      = {Philadelphia, Pa.},
      publisher    = {Wolters Kluwer},
      reportid     = {DZNE-2026-00194},
      pages        = {e200555},
      year         = {2026},
      abstract     = {The aim of this study was to analyze changes in hospital
                      incidence cases and disease severity of
                      autoantibody-associated autoimmune encephalitis (AE) during
                      the COVID-19 pandemic compared with the prepandemic period.A
                      retrospective multicenter study analyzed data from 24
                      centers within the German Network for Research on Autoimmune
                      Encephalitis (GENERATE). Patients with a new diagnosis of
                      definite antibody-positive autoimmune encephalitis from 2017
                      to 2022 were included and divided into prepandemic
                      (2017-2019) and pandemic (2020-2022) periods.Among 392
                      patients, 227 were diagnosed before and 165 during the
                      pandemic (mean 9.5 vs 6.9 per site, p = 0.04). A reduction
                      was observed in cases with antibodies to neuronal surface
                      antigens (174 vs 122 cases; mean 7.3 vs 5.1 per site, p =
                      0.02), while cases with antibodies against intracellular
                      antigens remained stable (p = 0.40). No differences were
                      observed in disease severity, age, or sex distribution
                      between periods.This study provides clinical data on
                      antibody-positive AE before and during the COVID-19
                      pandemic. The findings do not support the hypothesis that
                      SARS-CoV-2 infection triggers autoantibody-associated AE or
                      increases disease severity.},
      keywords     = {Humans / COVID-19: epidemiology / Male / Female / Middle
                      Aged / Retrospective Studies / Incidence / Encephalitis:
                      epidemiology / Encephalitis: immunology / Aged / Adult /
                      Germany: epidemiology / Hashimoto Disease: epidemiology /
                      Hashimoto Disease: immunology / Autoantibodies: blood /
                      Severity of Illness Index / Young Adult / Aged, 80 and over
                      / Hospitalization: statistics $\&$ numerical data /
                      Autoantibodies (NLM Chemicals)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41687038},
      doi          = {10.1212/NXI.0000000000200555},
      url          = {https://pub.dzne.de/record/285252},
}