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000285256 1001_ $$aArbaciauskaite, Skaiste$$b0
000285256 245__ $$aMicroglia-Derived Extracellular Vesicles from Alzheimer's Disease Patients Carry miRNAs Driving a Neuroinflammatory Response.
000285256 260__ $$aTotowa, NJ$$bHumana Press$$c2026
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000285256 520__ $$aAlzheimer's disease (AD) represents the most common cause of dementia and urgently requires sensitive biomarkers and effective therapies. Extracellular vesicles represent membranous nano-sized particles secreted from cells, which serve as intercellular messengers participating in central nervous system (CNS) homeostasis, but also are implicated in AD pathogenesis. In addition, EVs containing disease-specific signatures, such as microRNAs (miRNAs), are considered as potent tools for the diagnosis and treatment of AD and other brain disorders. In this study, we used TMEM119 antibody to immunocapture microglia-derived EVs from cerebrospinal fluid (CSF) of AD patients and control subjects. EVs harvested from these CSF samples contained distinct disease-specific miRNA profiles, as assessed by small RNA sequencing. Using a HEK TLR reporter cell system, we found that these miRNA are potent activators of human TLR8, an established RNA sensor. Out of the miRNAs present in AD-associated EVs, selected oligonucleotides were synthesized and loaded into BV2 microglia-derived EVs. Exposure of primary murine microglia to these miRNA-loaded EVs led to TNF release from these cells, thereby driving a neuroinflammatory response. Taken together, putatively microglia-derived EVs from the CSF of AD patients contain miRNAs, which are capable of activating hTLR8 and inducing an inflammatory response from microglia.
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000285256 650_7 $$2Other$$aAlzheimer’s disease
000285256 650_7 $$2Other$$aEV engineering
000285256 650_7 $$2Other$$aExtracellular vesicles
000285256 650_7 $$2Other$$aMicroRNA
000285256 650_7 $$2Other$$aMicroglia
000285256 650_7 $$2Other$$aRNA delivery
000285256 650_7 $$2Other$$aToll-like Receptors
000285256 650_7 $$2NLM Chemicals$$aMicroRNAs
000285256 650_2 $$2MeSH$$aMicroglia: metabolism
000285256 650_2 $$2MeSH$$aMicroglia: pathology
000285256 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000285256 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000285256 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000285256 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000285256 650_2 $$2MeSH$$aExtracellular Vesicles: metabolism
000285256 650_2 $$2MeSH$$aHumans
000285256 650_2 $$2MeSH$$aMicroRNAs: metabolism
000285256 650_2 $$2MeSH$$aMicroRNAs: genetics
000285256 650_2 $$2MeSH$$aAnimals
000285256 650_2 $$2MeSH$$aMice
000285256 650_2 $$2MeSH$$aNeuroinflammatory Diseases: genetics
000285256 650_2 $$2MeSH$$aNeuroinflammatory Diseases: pathology
000285256 650_2 $$2MeSH$$aNeuroinflammatory Diseases: metabolism
000285256 650_2 $$2MeSH$$aAged
000285256 650_2 $$2MeSH$$aMale
000285256 650_2 $$2MeSH$$aFemale
000285256 650_2 $$2MeSH$$aHEK293 Cells
000285256 650_2 $$2MeSH$$aAged, 80 and over
000285256 7001_ $$aSilvestri, Simona$$b1
000285256 7001_ $$aLuo, Pingyan$$b2
000285256 7001_ $$aKrüger, Christina$$b3
000285256 7001_ $$aMossmann, Zoe Julia$$b4
000285256 7001_ $$aAllelein, Susann$$b5
000285256 7001_ $$aScholz, Alexander$$b6
000285256 7001_ $$aLoeffler, Dennis$$b7
000285256 7001_ $$aFiorenza, Samuele$$b8
000285256 7001_ $$aMenale, Anna$$b9
000285256 7001_ $$aTorino, Enza$$b10
000285256 7001_ $$aKuhlmeier, Dirk$$b11
000285256 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b12$$udzne
000285256 7001_ $$aLehnardt, Seija$$b13
000285256 773__ $$0PERI:(DE-600)2079384-4$$a10.1007/s12035-026-05719-w$$gVol. 63, no. 1, p. 435$$n1$$p435$$tMolecular neurobiology$$v63$$x0893-7648$$y2026
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