Home > In process > Microglia-Derived Extracellular Vesicles from Alzheimer's Disease Patients Carry miRNAs Driving a Neuroinflammatory Response. > print

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024 7 _ |a 10.1007/s12035-026-05719-w
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024 7 _ |a 1559-1182
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037 _ _ |a DZNE-2026-00198
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Arbaciauskaite, Skaiste
|b 0
245 _ _ |a Microglia-Derived Extracellular Vesicles from Alzheimer's Disease Patients Carry miRNAs Driving a Neuroinflammatory Response.
260 _ _ |a Totowa, NJ
|c 2026
|b Humana Press
336 7 _ |a article
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520 _ _ |a Alzheimer's disease (AD) represents the most common cause of dementia and urgently requires sensitive biomarkers and effective therapies. Extracellular vesicles represent membranous nano-sized particles secreted from cells, which serve as intercellular messengers participating in central nervous system (CNS) homeostasis, but also are implicated in AD pathogenesis. In addition, EVs containing disease-specific signatures, such as microRNAs (miRNAs), are considered as potent tools for the diagnosis and treatment of AD and other brain disorders. In this study, we used TMEM119 antibody to immunocapture microglia-derived EVs from cerebrospinal fluid (CSF) of AD patients and control subjects. EVs harvested from these CSF samples contained distinct disease-specific miRNA profiles, as assessed by small RNA sequencing. Using a HEK TLR reporter cell system, we found that these miRNA are potent activators of human TLR8, an established RNA sensor. Out of the miRNAs present in AD-associated EVs, selected oligonucleotides were synthesized and loaded into BV2 microglia-derived EVs. Exposure of primary murine microglia to these miRNA-loaded EVs led to TNF release from these cells, thereby driving a neuroinflammatory response. Taken together, putatively microglia-derived EVs from the CSF of AD patients contain miRNAs, which are capable of activating hTLR8 and inducing an inflammatory response from microglia.
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650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a EV engineering
|2 Other
650 _ 7 |a Extracellular vesicles
|2 Other
650 _ 7 |a MicroRNA
|2 Other
650 _ 7 |a Microglia
|2 Other
650 _ 7 |a RNA delivery
|2 Other
650 _ 7 |a Toll-like Receptors
|2 Other
650 _ 7 |a MicroRNAs
|2 NLM Chemicals
650 _ 2 |a Microglia: metabolism
|2 MeSH
650 _ 2 |a Microglia: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: genetics
|2 MeSH
650 _ 2 |a Alzheimer Disease: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Extracellular Vesicles: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a MicroRNAs: metabolism
|2 MeSH
650 _ 2 |a MicroRNAs: genetics
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: genetics
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: pathology
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: metabolism
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a HEK293 Cells
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
700 1 _ |a Silvestri, Simona
|b 1
700 1 _ |a Luo, Pingyan
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700 1 _ |a Krüger, Christina
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700 1 _ |a Mossmann, Zoe Julia
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700 1 _ |a Allelein, Susann
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700 1 _ |a Scholz, Alexander
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700 1 _ |a Loeffler, Dennis
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700 1 _ |a Fiorenza, Samuele
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700 1 _ |a Menale, Anna
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700 1 _ |a Torino, Enza
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700 1 _ |a Kuhlmeier, Dirk
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700 1 _ |a Peters, Oliver
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700 1 _ |a Lehnardt, Seija
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773 _ _ |a 10.1007/s12035-026-05719-w
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|t Molecular neurobiology
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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