000285264 001__ 285264
000285264 005__ 20260219163023.0
000285264 0247_ $$2doi$$a10.1038/s41380-025-03230-7
000285264 0247_ $$2pmid$$apmid:41028570
000285264 0247_ $$2ISSN$$a1359-4184
000285264 0247_ $$2ISSN$$a1476-5578
000285264 037__ $$aDZNE-2026-00206
000285264 041__ $$aEnglish
000285264 082__ $$a610
000285264 1001_ $$00000-0001-6313-5939$$aButt, Umer Javed$$b0
000285264 245__ $$aForebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors.
000285264 260__ $$a[London]$$bSpringer Nature$$c2026
000285264 3367_ $$2DRIVER$$aarticle
000285264 3367_ $$2DataCite$$aOutput Types/Journal article
000285264 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1771514941_2909
000285264 3367_ $$2BibTeX$$aARTICLE
000285264 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000285264 3367_ $$00$$2EndNote$$aJournal Article
000285264 520__ $$aThe procognitive growth factor erythropoietin (EPO) and its canonical receptor, EPOR, have long been recognized to be expressed by most cell types in the brain. Cognitive domains, improved by injections of exogenous EPO or by endogenous, hypoxia-stimulated EPO, include important forebrain functions, namely attention, working memory, drive, and executive performance. To gain mechanistic insight into the involvement of forebrain-expressed EPO, we deleted EPO in mice using as specific cre-driver Emx1. Here, we report that these mutant mice act comparably to their wildtype littermates in a comprehensive behavioral test battery. Importantly, we find that the transcripts of both EPOR and a novel, brain-expressed EPO receptor, EphB4, respond to EPO deletion with compensatory upregulation. EphB4 expression in brain and its increase upon forebrain erasure of EPOR are confirmed by in situ hybridization and immunohistochemistry. The augmented expression of both EPOR and EphB4 and their regulatory intercorrelation may explain why EmxEPO mutants show an even superior performance in the most challenging working memory task. Using the previously published single-nuclei-RNA-seq dataset, we further confirm the suggested compensatory mechanism, wherein EPO loss or reduction drives elevated EPOR expression, adding another layer to the intricate regulation of EPO signaling in hippocampal pyramidal neurons. Collectively, these data may explain the lack of behavioral and negative cognitive consequences upon forebrain-wide EPO elimination.
000285264 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
000285264 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000285264 650_7 $$011096-26-7$$2NLM Chemicals$$aErythropoietin
000285264 650_7 $$2NLM Chemicals$$aReceptors, Erythropoietin
000285264 650_7 $$0EC 2.7.10.1$$2NLM Chemicals$$aReceptor, EphB4
000285264 650_7 $$2NLM Chemicals$$aEpo protein, mouse
000285264 650_2 $$2MeSH$$aAnimals
000285264 650_2 $$2MeSH$$aErythropoietin: metabolism
000285264 650_2 $$2MeSH$$aErythropoietin: genetics
000285264 650_2 $$2MeSH$$aProsencephalon: metabolism
000285264 650_2 $$2MeSH$$aReceptors, Erythropoietin: metabolism
000285264 650_2 $$2MeSH$$aReceptors, Erythropoietin: genetics
000285264 650_2 $$2MeSH$$aMice
000285264 650_2 $$2MeSH$$aMemory, Short-Term: physiology
000285264 650_2 $$2MeSH$$aUp-Regulation
000285264 650_2 $$2MeSH$$aReceptor, EphB4: metabolism
000285264 650_2 $$2MeSH$$aReceptor, EphB4: genetics
000285264 650_2 $$2MeSH$$aMale
000285264 650_2 $$2MeSH$$aHippocampus: metabolism
000285264 650_2 $$2MeSH$$aSignal Transduction
000285264 650_2 $$2MeSH$$aBrain: metabolism
000285264 650_2 $$2MeSH$$aMice, Inbred C57BL
000285264 650_2 $$2MeSH$$aMice, Transgenic
000285264 650_2 $$2MeSH$$aMice, Knockout
000285264 650_2 $$2MeSH$$aCognition: physiology
000285264 7001_ $$00000-0003-2835-3003$$aÇakır, Umut$$b1
000285264 7001_ $$00009-0005-3534-3884$$aWildenburg, Anne-Fleur$$b2
000285264 7001_ $$00000-0001-8087-360X$$aCurto, Yasmina$$b3
000285264 7001_ $$aYe, Liu$$b4
000285264 7001_ $$0P:(DE-2719)2812055$$aBansal, Vikas$$b5$$udzne
000285264 7001_ $$00000-0003-2792-7423$$aBoretius, Susann$$b6
000285264 7001_ $$00000-0001-8724-9666$$aNave, Klaus-Armin$$b7
000285264 7001_ $$00000-0002-8626-5418$$aSingh, Manvendra$$b8
000285264 7001_ $$00000-0001-8371-5711$$aEhrenreich, Hannelore$$b9
000285264 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-025-03230-7$$gVol. 31, no. 3, p. 1241 - 1252$$n3$$p1241 - 1252$$tMolecular psychiatry$$v31$$x1359-4184$$y2026
000285264 8564_ $$uhttps://pub.dzne.de/record/285264/files/DZNE-2026-00206.pdf$$yRestricted
000285264 8564_ $$uhttps://pub.dzne.de/record/285264/files/DZNE-2026-00206.pdf?subformat=pdfa$$xpdfa$$yRestricted
000285264 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812055$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000285264 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x0
000285264 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2025-11-07$$wger
000285264 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bMOL PSYCHIATR : 2022$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2025-11-07
000285264 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bMOL PSYCHIATR : 2022$$d2025-11-07
000285264 9201_ $$0I:(DE-2719)1210013$$kAG Bansal$$lBiomedical Data Science$$x0
000285264 980__ $$ajournal
000285264 980__ $$aEDITORS
000285264 980__ $$aVDBINPRINT
000285264 980__ $$aI:(DE-2719)1210013
000285264 980__ $$aUNRESTRICTED