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@ARTICLE{Ye:285265,
      author       = {Ye, L. and Seidler, L. and Chemodanow, D. and Respondek, G.
                      and Niesmann, C. and Wilkens, I. and Klietz, M. and
                      Höglinger, G. U. and Kopp, B.},
      title        = {{E}xecutive anosognosia in progressive supranuclear palsy
                      versus {P}arkinson's disease.},
      journal      = {Frontiers in neurology},
      volume       = {17},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2026-00207},
      pages        = {1744979},
      year         = {2026},
      abstract     = {Executive function deficits are common among patients with
                      Parkinson's disease (PD) and progressive supranuclear palsy
                      (PSP). Executive function refers to higher-order cognitive
                      processes thought to involve fronto-striatal circuits. Some
                      patients with executive deficits may be unable to recognize
                      or report them, a condition we refer to as executive
                      anosognosia.To conduct a comparative analysis of executive
                      anosognosia in patients diagnosed with PSP and PD.We
                      compared an objective neuropsychological assessment (ONA) of
                      composite executive function (ONA-CEF), which includes
                      semantic and phonemic verbal fluency, as well as two
                      sub-scores from the Wisconsin Card Sorting Test, with
                      patient- and informant-reported rating scales. We used the
                      Dysexecutive Questionnaire Revised (DEX-R) to evaluate
                      near-transfer executive complaints and the Aachen Activity
                      and Participation Index: Cognition and Participation
                      (AAPI-CP) composite to evaluate far-transfer cognitive and
                      social difficulties. Discrepancy indices were calculated for
                      patients and informants (ONA-CEF minus DEX-R and ONA-CEF
                      minus AAPI-CP).PSP patients had significantly larger
                      negative discrepancies than PD patients, indicating stronger
                      executive anosognosia. Although informant reports reduced
                      these discrepancies, significant underreporting persisted in
                      PSP informants. Correlational analyses revealed that
                      patient-reported DEX-R difficulties were strongly correlated
                      with depressive symptoms (r ≈ 0.65) but not with objective
                      executive performance (r ≈ 0.00).Executive anosognosia is
                      a marker of PSP, highlighting the need for objective
                      neuropsychological assessments in clinical trials. PSP
                      patients' reports of executive dysfunction are more
                      associated with mood than actual impairment, which
                      challenges the validity of patient-reported outcomes in PSP
                      and related neurological diseases.},
      keywords     = {Parkinson’s disease (Other) / anosognosia (Other) /
                      executive function (Other) / patient-reported outcome
                      measures (Other) / progressive supranuclear palsy (Other)},
      cin          = {Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41704890},
      pmc          = {pmc:PMC12907162},
      doi          = {10.3389/fneur.2026.1744979},
      url          = {https://pub.dzne.de/record/285265},
}