000285267 001__ 285267
000285267 005__ 20260219164623.0
000285267 0247_ $$2doi$$a10.1038/s44400-025-00047-7
000285267 0247_ $$2pmid$$apmid:41709913
000285267 0247_ $$2pmc$$apmc:PMC12909123
000285267 037__ $$aDZNE-2026-00209
000285267 041__ $$aEnglish
000285267 1001_ $$aDaniels, Alisha J$$b0
000285267 245__ $$a15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN.
000285267 260__ $$c2026
000285267 3367_ $$2DRIVER$$aarticle
000285267 3367_ $$2DataCite$$aOutput Types/Journal article
000285267 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1771515689_3093
000285267 3367_ $$2BibTeX$$aARTICLE
000285267 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000285267 3367_ $$00$$2EndNote$$aJournal Article
000285267 500__ $$aMissing Journal: npj Dementia (npj Dement.) = 3005-1940 (import from CrossRef, PubMed, , Journals: pub.dzne.de)
000285267 520__ $$aThe Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer's disease (ADAD), a rare monogenic form of Alzheimer's disease (AD). Established in 2008 with support from the National Institute on Aging (NIA), DIAN Obs is designed to collect comprehensive and uniform data with the aim to characterize brain biology and clinical trajectory of individuals at risk for ADAD. Mutations in the amyloid protein precursor (APP), presenilin 1 (PSEN1), or presenilin 2 (PSEN2) genes cause ADAD with virtually full penetrance and a predictable age at symptomatic onset. Participants, both mutation carriers and non-carriers from affected families, undergo longitudinal clinical and cognitive assessments, neurologic and physical examinations, structural and functional neuro-imaging, and amyloid and tau positron emission tomography (PET). Biospecimens include cerebrospinal fluid, plasma, serum, and whole blood for biochemical, genetic and multi-omic analyses, with brain donation upon death. This dataset enables one of the most detailed longitudinal examinations of the human brain across the continuum from presymptomatic to symptomatic AD. The extensive DIAN Obs data and biospecimen repository provides a globally accessible resource to advance understanding of AD pathophysiology, aging, and the development of preventive and therapeutic interventions.
000285267 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000285267 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x1
000285267 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000285267 650_7 $$2Other$$aAlzheimer's disease
000285267 650_7 $$2Other$$aCognitive neuroscience
000285267 650_7 $$2Other$$aDiagnostic markers
000285267 650_7 $$2Other$$aGenetic markers
000285267 650_7 $$2Other$$aPredictive markers
000285267 650_7 $$2Other$$aPrognostic markers
000285267 7001_ $$aMcDade, Eric$$b1
000285267 7001_ $$aLlibre-Guerra, Jorge J$$b2
000285267 7001_ $$aXiong, Chengjie$$b3
000285267 7001_ $$aPerrin, Richard J$$b4
000285267 7001_ $$aIbanez, Laura$$b5
000285267 7001_ $$aSupnet-Bell, Charlene$$b6
000285267 7001_ $$aCruchaga, Carlos$$b7
000285267 7001_ $$aGoate, Alison$$b8
000285267 7001_ $$aRenton, Alan E$$b9
000285267 7001_ $$aBenzinger, Tammie L S$$b10
000285267 7001_ $$aGordon, Brian A$$b11
000285267 7001_ $$aHassenstab, Jason$$b12
000285267 7001_ $$aKarch, Celeste$$b13
000285267 7001_ $$aLevey, Allan$$b14
000285267 7001_ $$aMorris, John C$$b15
000285267 7001_ $$aBuckles, Virginia$$b16
000285267 7001_ $$aAllegri, Ricardo F$$b17
000285267 7001_ $$aChrem, Patricio$$b18
000285267 7001_ $$aBerman, Sarah B$$b19
000285267 7001_ $$aChhatwal, Jasmeer P$$b20
000285267 7001_ $$aFarlow, Martin R$$b21
000285267 7001_ $$aFox, Nick C$$b22
000285267 7001_ $$aDay, Gregory S$$b23
000285267 7001_ $$aIkeuchi, Takeshi$$b24
000285267 7001_ $$0P:(DE-2719)2000010$$aJucker, Mathias$$b25$$udzne
000285267 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b26$$udzne
000285267 7001_ $$0P:(DE-HGF)0$$aLee, Jae-Hong$$b27
000285267 7001_ $$aAguillon, David$$b28
000285267 7001_ $$aTakada, Leonel$$b29
000285267 7001_ $$aSosa, Ana Luisa$$b30
000285267 7001_ $$aMartins, Ralph$$b31
000285267 7001_ $$aMori, Hiroshi$$b32
000285267 7001_ $$aNoble, James M$$b33
000285267 7001_ $$aSalloway, Stephen$$b34
000285267 7001_ $$aHuey, Edward$$b35
000285267 7001_ $$aSánchez-Valle, Raquel$$b36
000285267 7001_ $$aSchofield, Peter R$$b37
000285267 7001_ $$aRoh, Jee Hoon$$b38
000285267 7001_ $$aBateman, Randall J$$b39
000285267 7001_ $$aNetwork, Dominantly Inherited Alzheimer$$b40$$eCollaboration Author
000285267 7001_ $$aDaniels, Alisha J$$b41$$eContributor
000285267 7001_ $$aMcDade, Eric$$b42$$eContributor
000285267 7001_ $$aLlibre-Guerra, Jorge J$$b43$$eContributor
000285267 7001_ $$aXiong, Chengjie$$b44$$eContributor
000285267 7001_ $$aPerrin, Richard J$$b45$$eContributor
000285267 7001_ $$aIbanez, Laura$$b46$$eContributor
000285267 7001_ $$aSupnet-Bell, Charlene$$b47$$eContributor
000285267 7001_ $$aCruchaga, Carlos$$b48$$eContributor
000285267 7001_ $$aGoate, Alison$$b49$$eContributor
000285267 7001_ $$aRenton, Alan E$$b50$$eContributor
000285267 7001_ $$aGordon, Brian A$$b51$$eContributor
000285267 7001_ $$aHassenstab, Jason$$b52$$eContributor
000285267 7001_ $$aKarch, Celeste$$b53$$eContributor
000285267 7001_ $$aLevey, Allan$$b54$$eContributor
000285267 7001_ $$aMorris, John C$$b55$$eContributor
000285267 7001_ $$aBuckles, Virginia$$b56$$eContributor
000285267 7001_ $$aAllegri, Ricardo F$$b57$$eContributor
000285267 7001_ $$aChrem, Patricio$$b58$$eContributor
000285267 7001_ $$aBerman, Sarah B$$b59$$eContributor
000285267 7001_ $$aChhatwal, Jasmeer P$$b60$$eContributor
000285267 7001_ $$aFarlow, Martin R$$b61$$eContributor
000285267 7001_ $$aFox, Nick C$$b62$$eContributor
000285267 7001_ $$aDay, Gregory S$$b63$$eContributor
000285267 7001_ $$aIkeuchi, Takeshi$$b64$$eContributor
000285267 7001_ $$0P:(DE-2719)2000010$$aJucker, Mathias$$b65$$eContributor$$udzne
000285267 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b66$$eContributor$$udzne
000285267 7001_ $$0P:(DE-HGF)0$$aLee, Jae-Hong$$b67$$eContributor
000285267 7001_ $$aAguillon, David$$b68$$eContributor
000285267 7001_ $$aTakada, Leonel$$b69$$eContributor
000285267 7001_ $$aSosa, Ana Luisa$$b70$$eContributor
000285267 7001_ $$aMartins, Ralph$$b71$$eContributor
000285267 7001_ $$aMori, Hiroshi$$b72$$eContributor
000285267 7001_ $$aNoble, James M$$b73$$eContributor
000285267 7001_ $$aSalloway, Stephen$$b74$$eContributor
000285267 7001_ $$aHuey, Edward$$b75$$eContributor
000285267 7001_ $$aSánchez-Valle, Raquel$$b76$$eContributor
000285267 7001_ $$aSchofield, Peter R$$b77$$eContributor
000285267 7001_ $$aRoh, Jee Hoon$$b78$$eContributor
000285267 7001_ $$aBateman, Randall J$$b79$$eContributor
000285267 7001_ $$aBenzinger, Tammie L S$$b80$$eContributor
000285267 7001_ $$aHoltzman, David M$$b81$$eContributor
000285267 7001_ $$aFagan, Anne M$$b82$$eContributor
000285267 7001_ $$aFranklin, Erin$$b83$$eContributor
000285267 7001_ $$aXu, Xiong$$b84$$eContributor
000285267 7001_ $$aLu, Ruijin$$b85$$eContributor
000285267 7001_ $$aWang, Guoqiao$$b86$$eContributor
000285267 7001_ $$aLi, Yan$$b87$$eContributor
000285267 7001_ $$aGremminger, Emily$$b88$$eContributor
000285267 7001_ $$aCourtney, Laura$$b89$$eContributor
000285267 7001_ $$aJerome, Gina$$b90$$eContributor
000285267 7001_ $$aHerries, Elizabeth$$b91$$eContributor
000285267 7001_ $$aStauber, Jennifer$$b92$$eContributor
000285267 7001_ $$aBaker, Bryce$$b93$$eContributor
000285267 7001_ $$aMinton, Matthew$$b94$$eContributor
000285267 7001_ $$aPicarello, Danielle M$$b95$$eContributor
000285267 7001_ $$aHornbeck, Russ$$b96$$eContributor
000285267 7001_ $$aChen, Allison$$b97$$eContributor
000285267 7001_ $$aChen, Charles$$b98$$eContributor
000285267 7001_ $$aFlores, Shaney$$b99$$eContributor
000285267 7001_ $$aJoseph-Mathurin, Nelly$$b100$$eContributor
000285267 7001_ $$aJarman, Steve$$b101$$eContributor
000285267 7001_ $$aJackson, Kelley$$b102$$eContributor
000285267 7001_ $$aKeefe, Sarah$$b103$$eContributor
000285267 7001_ $$aKoudelis, Deborah$$b104$$eContributor
000285267 7001_ $$aMassoumzadeh, Parinaz$$b105$$eContributor
000285267 7001_ $$aMcCullough, Austin$$b106$$eContributor
000285267 7001_ $$aMcKay, Nicole$$b107$$eContributor
000285267 7001_ $$aNicklaus, Joyce$$b108$$eContributor
000285267 7001_ $$aPulizos, Christine$$b109$$eContributor
000285267 7001_ $$aWang, Qing$$b110$$eContributor
000285267 7001_ $$aSabaredzovic, Edita$$b111$$eContributor
000285267 7001_ $$aSmith, Hunter$$b112$$eContributor
000285267 7001_ $$aScott, Jalen$$b113$$eContributor
000285267 7001_ $$aSimmons, Ashlee$$b114$$eContributor
000285267 7001_ $$aRizzo, Jacqueline$$b115$$eContributor
000285267 7001_ $$aSullivan, Jennifer$$b116$$eContributor
000285267 7001_ $$aStout, Sarah$$b117$$eContributor
000285267 7001_ $$aAschenbrenner, Andrew J$$b118$$eContributor
000285267 7001_ $$aMarsh, Jacob$$b119$$eContributor
000285267 7001_ $$aBarthelemy, Nicolas$$b120$$eContributor
000285267 7001_ $$aXu, Jinbin$$b121$$eContributor
000285267 7001_ $$aJohnson, Erik C B$$b122$$eContributor
000285267 7001_ $$aSeyfried, Nicholas T$$b123$$eContributor
000285267 7001_ $$aSurace, Ezequiel$$b124$$eContributor
000285267 7001_ $$aVazquez, Silvia$$b125$$eContributor
000285267 7001_ $$aIkonomovic, Snezana$$b126$$eContributor
000285267 7001_ $$aNadkarni, Neelesh K$$b127$$eContributor
000285267 7001_ $$aCash, David M$$b128$$eContributor
000285267 7001_ $$aRyan, Natalie S$$b129$$eContributor
000285267 7001_ $$aGraff-Radford, Neill R$$b130$$eContributor
000285267 7001_ $$aKasuga, Kensaku$$b131$$eContributor
000285267 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b132$$eContributor$$udzne
000285267 7001_ $$0P:(DE-2719)2814244$$aHofmann, Anna$$b133$$eContributor$$udzne
000285267 7001_ $$0P:(DE-2719)2810869$$aKuder-Buletta, Elke$$b134$$eContributor$$udzne
000285267 7001_ $$0P:(DE-2719)2810662$$aGräber-Sultan, Susanne$$b135$$eContributor$$udzne
000285267 7001_ $$aObermueller, Ulrike$$b136$$eContributor
000285267 7001_ $$0P:(DE-2719)2810668$$aRoedenbeck, Yvonne$$b137$$eContributor
000285267 7001_ $$0P:(DE-2719)2811820$$aVöglein, Jonathan$$b138$$eContributor$$udzne
000285267 7001_ $$aLopera, Francisco$$b139$$eContributor
000285267 7001_ $$aMilena, Yudy$$b140$$eContributor
000285267 7001_ $$aRamirez, Laura$$b141$$eContributor
000285267 7001_ $$aBrooks, William S$$b142$$eContributor
000285267 7001_ $$aBechara, Jacob A$$b143$$eContributor
000285267 7001_ $$aNiimi, Yoshiki$$b144$$eContributor
000285267 7001_ $$aRosa-Neto, Pedro$$b145$$eContributor
000285267 7001_ $$aRingman, John$$b146$$eContributor
000285267 7001_ $$aMasters, Colin$$b147$$eContributor
000285267 773__ $$0PERI:(DE-600)0000000-0$$a10.1038/s44400-025-00047-7$$gVol. 2, no. 1, p. 13$$n1$$p13$$tMissing Journal / Fehlende Zeitschrift$$v2$$y2026
000285267 8564_ $$uhttps://pub.dzne.de/record/285267/files/DZNE-2026-00209.pdf$$yRestricted
000285267 8564_ $$uhttps://pub.dzne.de/record/285267/files/DZNE-2026-00209.pdf?subformat=pdfa$$xpdfa$$yRestricted
000285267 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000010$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b25$$kDZNE
000285267 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811659$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b26$$kDZNE
000285267 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2000010$$aExternal Institute$$b65$$kExtern
000285267 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811659$$aExternal Institute$$b66$$kExtern
000285267 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2000055$$aExternal Institute$$b132$$kExtern
000285267 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2814244$$aExternal Institute$$b133$$kExtern
000285267 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810869$$aExternal Institute$$b134$$kExtern
000285267 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810662$$aExternal Institute$$b135$$kExtern
000285267 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811820$$aExternal Institute$$b138$$kExtern
000285267 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000285267 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x1
000285267 9201_ $$0I:(DE-2719)1210001$$kAG Jucker$$lCell Biology of Neurological Diseases$$x0
000285267 9201_ $$0I:(DE-2719)1111015$$kClinical Research (Munich)$$lClinical Research (Munich)$$x1
000285267 9201_ $$0I:(DE-2719)1111016$$kAG Levin$$lClinical Neurodegeneration$$x2
000285267 980__ $$ajournal
000285267 980__ $$aEDITORS
000285267 980__ $$aVDBINPRINT
000285267 980__ $$aI:(DE-2719)1210001
000285267 980__ $$aI:(DE-2719)1111015
000285267 980__ $$aI:(DE-2719)1111016
000285267 980__ $$aUNRESTRICTED