TY  - JOUR
AU  - Daniels, Alisha J
AU  - McDade, Eric
AU  - Llibre-Guerra, Jorge J
AU  - Xiong, Chengjie
AU  - Perrin, Richard J
AU  - Ibanez, Laura
AU  - Supnet-Bell, Charlene
AU  - Cruchaga, Carlos
AU  - Goate, Alison
AU  - Renton, Alan E
AU  - Benzinger, Tammie L S
AU  - Gordon, Brian A
AU  - Hassenstab, Jason
AU  - Karch, Celeste
AU  - Levey, Allan
AU  - Morris, John C
AU  - Buckles, Virginia
AU  - Allegri, Ricardo F
AU  - Chrem, Patricio
AU  - Berman, Sarah B
AU  - Chhatwal, Jasmeer P
AU  - Farlow, Martin R
AU  - Fox, Nick C
AU  - Day, Gregory S
AU  - Ikeuchi, Takeshi
AU  - Jucker, Mathias
AU  - Levin, Johannes
AU  - Lee, Jae-Hong
AU  - Aguillon, David
AU  - Takada, Leonel
AU  - Sosa, Ana Luisa
AU  - Martins, Ralph
AU  - Mori, Hiroshi
AU  - Noble, James M
AU  - Salloway, Stephen
AU  - Huey, Edward
AU  - Sánchez-Valle, Raquel
AU  - Schofield, Peter R
AU  - Roh, Jee Hoon
AU  - Bateman, Randall J
TI  - 15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN.
JO  - Missing Journal / Fehlende Zeitschrift
VL  - 2
IS  - 1
M1  - DZNE-2026-00209
SP  - 13
PY  - 2026
N1  - Missing Journal: npj Dementia (npj Dement.) = 3005-1940 (import from CrossRef, PubMed, , Journals: pub.dzne.de)
AB  - The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer's disease (ADAD), a rare monogenic form of Alzheimer's disease (AD). Established in 2008 with support from the National Institute on Aging (NIA), DIAN Obs is designed to collect comprehensive and uniform data with the aim to characterize brain biology and clinical trajectory of individuals at risk for ADAD. Mutations in the amyloid protein precursor (APP), presenilin 1 (PSEN1), or presenilin 2 (PSEN2) genes cause ADAD with virtually full penetrance and a predictable age at symptomatic onset. Participants, both mutation carriers and non-carriers from affected families, undergo longitudinal clinical and cognitive assessments, neurologic and physical examinations, structural and functional neuro-imaging, and amyloid and tau positron emission tomography (PET). Biospecimens include cerebrospinal fluid, plasma, serum, and whole blood for biochemical, genetic and multi-omic analyses, with brain donation upon death. This dataset enables one of the most detailed longitudinal examinations of the human brain across the continuum from presymptomatic to symptomatic AD. The extensive DIAN Obs data and biospecimen repository provides a globally accessible resource to advance understanding of AD pathophysiology, aging, and the development of preventive and therapeutic interventions.
KW  - Alzheimer's disease (Other)
KW  - Cognitive neuroscience (Other)
KW  - Diagnostic markers (Other)
KW  - Genetic markers (Other)
KW  - Predictive markers (Other)
KW  - Prognostic markers (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41709913
C2  - pmc:PMC12909123
DO  - DOI:10.1038/s44400-025-00047-7
UR  - https://pub.dzne.de/record/285267
ER  -