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@ARTICLE{Daniels:285267,
author = {Daniels, Alisha J and McDade, Eric and Llibre-Guerra, Jorge
J and Xiong, Chengjie and Perrin, Richard J and Ibanez,
Laura and Supnet-Bell, Charlene and Cruchaga, Carlos and
Goate, Alison and Renton, Alan E and Benzinger, Tammie L S
and Gordon, Brian A and Hassenstab, Jason and Karch, Celeste
and Levey, Allan and Morris, John C and Buckles, Virginia
and Allegri, Ricardo F and Chrem, Patricio and Berman, Sarah
B and Chhatwal, Jasmeer P and Farlow, Martin R and Fox, Nick
C and Day, Gregory S and Ikeuchi, Takeshi and Jucker,
Mathias and Levin, Johannes and Lee, Jae-Hong and Aguillon,
David and Takada, Leonel and Sosa, Ana Luisa and Martins,
Ralph and Mori, Hiroshi and Noble, James M and Salloway,
Stephen and Huey, Edward and Sánchez-Valle, Raquel and
Schofield, Peter R and Roh, Jee Hoon and Bateman, Randall J},
collaboration = {Network, Dominantly Inherited Alzheimer},
othercontributors = {Daniels, Alisha J and McDade, Eric and Llibre-Guerra, Jorge
J and Xiong, Chengjie and Perrin, Richard J and Ibanez,
Laura and Supnet-Bell, Charlene and Cruchaga, Carlos and
Goate, Alison and Renton, Alan E and Gordon, Brian A and
Hassenstab, Jason and Karch, Celeste and Levey, Allan and
Morris, John C and Buckles, Virginia and Allegri, Ricardo F
and Chrem, Patricio and Berman, Sarah B and Chhatwal,
Jasmeer P and Farlow, Martin R and Fox, Nick C and Day,
Gregory S and Ikeuchi, Takeshi and Jucker, Mathias and
Levin, Johannes and Lee, Jae-Hong and Aguillon, David and
Takada, Leonel and Sosa, Ana Luisa and Martins, Ralph and
Mori, Hiroshi and Noble, James M and Salloway, Stephen and
Huey, Edward and Sánchez-Valle, Raquel and Schofield, Peter
R and Roh, Jee Hoon and Bateman, Randall J and Benzinger,
Tammie L S and Holtzman, David M and Fagan, Anne M and
Franklin, Erin and Xu, Xiong and Lu, Ruijin and Wang,
Guoqiao and Li, Yan and Gremminger, Emily and Courtney,
Laura and Jerome, Gina and Herries, Elizabeth and Stauber,
Jennifer and Baker, Bryce and Minton, Matthew and Picarello,
Danielle M and Hornbeck, Russ and Chen, Allison and Chen,
Charles and Flores, Shaney and Joseph-Mathurin, Nelly and
Jarman, Steve and Jackson, Kelley and Keefe, Sarah and
Koudelis, Deborah and Massoumzadeh, Parinaz and McCullough,
Austin and McKay, Nicole and Nicklaus, Joyce and Pulizos,
Christine and Wang, Qing and Sabaredzovic, Edita and Smith,
Hunter and Scott, Jalen and Simmons, Ashlee and Rizzo,
Jacqueline and Sullivan, Jennifer and Stout, Sarah and
Aschenbrenner, Andrew J and Marsh, Jacob and Barthelemy,
Nicolas and Xu, Jinbin and Johnson, Erik C B and Seyfried,
Nicholas T and Surace, Ezequiel and Vazquez, Silvia and
Ikonomovic, Snezana and Nadkarni, Neelesh K and Cash, David
M and Ryan, Natalie S and Graff-Radford, Neill R and Kasuga,
Kensaku and Laske, Christoph and Hofmann, Anna and
Kuder-Buletta, Elke and Gräber-Sultan, Susanne and
Obermueller, Ulrike and Roedenbeck, Yvonne and Vöglein,
Jonathan and Lopera, Francisco and Milena, Yudy and Ramirez,
Laura and Brooks, William S and Bechara, Jacob A and Niimi,
Yoshiki and Rosa-Neto, Pedro and Ringman, John and Masters,
Colin},
title = {15 years of longitudinal genetic, clinical, cognitive,
imaging, and biochemical measures in {DIAN}.},
journal = {Missing Journal / Fehlende Zeitschrift},
volume = {2},
number = {1},
reportid = {DZNE-2026-00209},
pages = {13},
year = {2026},
note = {Missing Journal: npj Dementia (npj Dement.) = 3005-1940
(import from CrossRef, PubMed, , Journals: pub.dzne.de)},
abstract = {The Dominantly Inherited Alzheimer Network Observational
Study (DIAN Obs) is a longitudinal, global cohort study
investigating brain aging and autosomal dominant Alzheimer's
disease (ADAD), a rare monogenic form of Alzheimer's disease
(AD). Established in 2008 with support from the National
Institute on Aging (NIA), DIAN Obs is designed to collect
comprehensive and uniform data with the aim to characterize
brain biology and clinical trajectory of individuals at risk
for ADAD. Mutations in the amyloid protein precursor (APP),
presenilin 1 (PSEN1), or presenilin 2 (PSEN2) genes cause
ADAD with virtually full penetrance and a predictable age at
symptomatic onset. Participants, both mutation carriers and
non-carriers from affected families, undergo longitudinal
clinical and cognitive assessments, neurologic and physical
examinations, structural and functional neuro-imaging, and
amyloid and tau positron emission tomography (PET).
Biospecimens include cerebrospinal fluid, plasma, serum, and
whole blood for biochemical, genetic and multi-omic
analyses, with brain donation upon death. This dataset
enables one of the most detailed longitudinal examinations
of the human brain across the continuum from presymptomatic
to symptomatic AD. The extensive DIAN Obs data and
biospecimen repository provides a globally accessible
resource to advance understanding of AD pathophysiology,
aging, and the development of preventive and therapeutic
interventions.},
keywords = {Alzheimer's disease (Other) / Cognitive neuroscience
(Other) / Diagnostic markers (Other) / Genetic markers
(Other) / Predictive markers (Other) / Prognostic markers
(Other)},
cin = {AG Jucker / Clinical Research (Munich) / AG Levin},
cid = {I:(DE-2719)1210001 / I:(DE-2719)1111015 /
I:(DE-2719)1111016},
pnm = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:41709913},
pmc = {pmc:PMC12909123},
doi = {10.1038/s44400-025-00047-7},
url = {https://pub.dzne.de/record/285267},
}
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