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000285268 1001_ $$0P:(DE-2719)9001484$$aBergmann, Carina$$b0$$eFirst author$$udzne
000285268 245__ $$aNeurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality.
000285268 260__ $$aLawrence, KS$$bPLoS$$c2026
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000285268 520__ $$aBlood levels of neurofilament light chain (NfL) increase with age in healthy humans and have been shown to predict all-cause human mortality. To determine whether this relationship is conserved across species, we analyzed NfL in the blood of various animals. We observed age-related increases in NfL levels comparable to those seen in humans in mice, cats, dogs and horses. Longitudinal analysis of NfL trajectories in aged mice demonstrated that a faster rate of NfL increase predicts mortality. When comparing baseline NfL levels across 13 species, we found that those with lower baseline NfL levels tended to have longer lifespans; however, the collinearity between body size and life span complicates the interpretation of this finding. NfL was also robustly detected in blood of 39 additional mammalian species, as well as a few reptiles and birds, consistent with a conserved amino acid sequence of the NfL fragment in blood. Given the growing interest in NfL as a biomarker for neurological health and mortality in humans, our findings suggest that NfL may serve as a cross-species blood biomarker for assessing aging interventions and predicting mortality.
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000285268 650_7 $$2NLM Chemicals$$aNeurofilament Proteins
000285268 650_7 $$2NLM Chemicals$$aBiomarkers
000285268 650_7 $$2NLM Chemicals$$aneurofilament protein L
000285268 650_2 $$2MeSH$$aNeurofilament Proteins: blood
000285268 650_2 $$2MeSH$$aAnimals
000285268 650_2 $$2MeSH$$aBiomarkers: blood
000285268 650_2 $$2MeSH$$aAging: blood
000285268 650_2 $$2MeSH$$aHumans
000285268 650_2 $$2MeSH$$aMice
000285268 650_2 $$2MeSH$$aDogs
000285268 650_2 $$2MeSH$$aMale
000285268 650_2 $$2MeSH$$aCats
000285268 650_2 $$2MeSH$$aFemale
000285268 650_2 $$2MeSH$$aLongevity
000285268 650_2 $$2MeSH$$aSpecies Specificity
000285268 650_2 $$2MeSH$$aHorses
000285268 7001_ $$0P:(DE-2719)2811581$$aHäsler, Lisa M$$b1$$udzne
000285268 7001_ $$0P:(DE-2719)2810762$$aLambert, Marius$$b2$$udzne
000285268 7001_ $$0P:(DE-2719)9000387$$aKaeser, Stephan A$$b3$$udzne
000285268 7001_ $$aSchultz, Stephanie A$$b4
000285268 7001_ $$aRiond, Barbara$$b5
000285268 7001_ $$aWeiss, Marco$$b6
000285268 7001_ $$aBalz, Martina$$b7
000285268 7001_ $$aKnauf-Witzens, Tobias$$b8
000285268 7001_ $$0P:(DE-2719)2000010$$aJucker, Mathias$$b9$$eLast author
000285268 773__ $$0PERI:(DE-600)2126773-X$$a10.1371/journal.pbio.3003606$$gVol. 24, no. 2, p. e3003606 -$$n2$$pe3003606$$tPLoS biology$$v24$$x1544-9173$$y2026
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