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@ARTICLE{Bergmann:285268,
      author       = {Bergmann, Carina and Häsler, Lisa M and Lambert, Marius
                      and Kaeser, Stephan A and Schultz, Stephanie A and Riond,
                      Barbara and Weiss, Marco and Balz, Martina and
                      Knauf-Witzens, Tobias and Jucker, Mathias},
      title        = {{N}eurofilament light chain may serve as a cross-species
                      blood biomarker to assess aging and predict mortality.},
      journal      = {PLoS biology},
      volume       = {24},
      number       = {2},
      issn         = {1544-9173},
      address      = {Lawrence, KS},
      publisher    = {PLoS},
      reportid     = {DZNE-2026-00210},
      pages        = {e3003606},
      year         = {2026},
      abstract     = {Blood levels of neurofilament light chain (NfL) increase
                      with age in healthy humans and have been shown to predict
                      all-cause human mortality. To determine whether this
                      relationship is conserved across species, we analyzed NfL in
                      the blood of various animals. We observed age-related
                      increases in NfL levels comparable to those seen in humans
                      in mice, cats, dogs and horses. Longitudinal analysis of NfL
                      trajectories in aged mice demonstrated that a faster rate of
                      NfL increase predicts mortality. When comparing baseline NfL
                      levels across 13 species, we found that those with lower
                      baseline NfL levels tended to have longer lifespans;
                      however, the collinearity between body size and life span
                      complicates the interpretation of this finding. NfL was also
                      robustly detected in blood of 39 additional mammalian
                      species, as well as a few reptiles and birds, consistent
                      with a conserved amino acid sequence of the NfL fragment in
                      blood. Given the growing interest in NfL as a biomarker for
                      neurological health and mortality in humans, our findings
                      suggest that NfL may serve as a cross-species blood
                      biomarker for assessing aging interventions and predicting
                      mortality.},
      keywords     = {Neurofilament Proteins: blood / Animals / Biomarkers: blood
                      / Aging: blood / Humans / Mice / Dogs / Male / Cats / Female
                      / Longevity / Species Specificity / Horses / Neurofilament
                      Proteins (NLM Chemicals) / Biomarkers (NLM Chemicals) /
                      neurofilament protein L (NLM Chemicals)},
      cin          = {AG Jucker},
      ddc          = {610},
      cid          = {I:(DE-2719)1210001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41712539},
      doi          = {10.1371/journal.pbio.3003606},
      url          = {https://pub.dzne.de/record/285268},
}