Home > In process > Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality. > print

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024 7 _ |a 10.1371/journal.pbio.3003606
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037 _ _ |a DZNE-2026-00210
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100 1 _ |a Bergmann, Carina
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245 _ _ |a Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality.
260 _ _ |a Lawrence, KS
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520 _ _ |a Blood levels of neurofilament light chain (NfL) increase with age in healthy humans and have been shown to predict all-cause human mortality. To determine whether this relationship is conserved across species, we analyzed NfL in the blood of various animals. We observed age-related increases in NfL levels comparable to those seen in humans in mice, cats, dogs and horses. Longitudinal analysis of NfL trajectories in aged mice demonstrated that a faster rate of NfL increase predicts mortality. When comparing baseline NfL levels across 13 species, we found that those with lower baseline NfL levels tended to have longer lifespans; however, the collinearity between body size and life span complicates the interpretation of this finding. NfL was also robustly detected in blood of 39 additional mammalian species, as well as a few reptiles and birds, consistent with a conserved amino acid sequence of the NfL fragment in blood. Given the growing interest in NfL as a biomarker for neurological health and mortality in humans, our findings suggest that NfL may serve as a cross-species blood biomarker for assessing aging interventions and predicting mortality.
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650 _ 7 |a Neurofilament Proteins
|2 NLM Chemicals
650 _ 7 |a Biomarkers
|2 NLM Chemicals
650 _ 7 |a neurofilament protein L
|2 NLM Chemicals
650 _ 2 |a Neurofilament Proteins: blood
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Biomarkers: blood
|2 MeSH
650 _ 2 |a Aging: blood
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Dogs
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Cats
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Longevity
|2 MeSH
650 _ 2 |a Species Specificity
|2 MeSH
650 _ 2 |a Horses
|2 MeSH
700 1 _ |a Häsler, Lisa M
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700 1 _ |a Lambert, Marius
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700 1 _ |a Kaeser, Stephan A
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700 1 _ |a Schultz, Stephanie A
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700 1 _ |a Riond, Barbara
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700 1 _ |a Weiss, Marco
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700 1 _ |a Balz, Martina
|b 7
700 1 _ |a Knauf-Witzens, Tobias
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700 1 _ |a Jucker, Mathias
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773 _ _ |a 10.1371/journal.pbio.3003606
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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