%0 Journal Article
%A Vöglein, Jonathan
%A Arzberger, Thomas
%A Ebner, Irena
%A Herms, Jochen
%A Roeber, Sigrun
%A Ruf, Viktoria
%A Danek, Adrian
%A Giese, Armin
%A Höglinger, Günter U
%A Levin, Johannes
%T Accuracy of clinical diagnosis in neurodegenerative diseases - a study of 455 autopsy cases.
%J Journal of neurology
%V 273
%N 2
%@ 0367-004X
%C [Darmstadt]
%I Steinkopff
%M DZNE-2026-00216
%P 156
%D 2026
%X Precision of clinical diagnosis in neurodegenerative diseases is critically important for clinical care and study recruitment. This study aimed to investigate the clinical accuracy using gold-standard neuropathological reference.Neuropathological diagnoses from the Neurobiobank München were correlated with real-world clinical diagnoses from hospitals in Germany. Accuracy metrics, including sensitivity, specificity, and area under the curve (AUC) of clinical diagnoses, were calculated.Among nine neuropathologically diagnosed neurodegenerative diseases (Alzheimer's disease, argyrophilic grain disease, corticobasal degeneration, frontotemporal lobar degeneration, Huntington's disease, Lewy body disease, motor neuron disease, multiple system atrophy, and progressive supranuclear palsy) with a total of 455 cases, clinical sensitivity varied widely (0-100
%K Humans
%K Neurodegenerative Diseases: diagnosis
%K Neurodegenerative Diseases: pathology
%K Male
%K Female
%K Aged
%K Middle Aged
%K Autopsy
%K Aged, 80 and over
%K Sensitivity and Specificity
%K Adult
%K Clinical diagnosis (Other)
%K Clinical–neuropathological correlation (Other)
%K Diagnostic accuracy (Other)
%K Neurodegenerative diseases (Other)
%K Neuropathology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41721140
%2 pmc:PMC12923403
%R 10.1007/s00415-026-13680-w
%U https://pub.dzne.de/record/285350