TY  - JOUR
AU  - Vöglein, Jonathan
AU  - Arzberger, Thomas
AU  - Ebner, Irena
AU  - Herms, Jochen
AU  - Roeber, Sigrun
AU  - Ruf, Viktoria
AU  - Danek, Adrian
AU  - Giese, Armin
AU  - Höglinger, Günter U
AU  - Levin, Johannes
TI  - Accuracy of clinical diagnosis in neurodegenerative diseases - a study of 455 autopsy cases.
JO  - Journal of neurology
VL  - 273
IS  - 2
SN  - 0367-004X
CY  - [Darmstadt]
PB  - Steinkopff
M1  - DZNE-2026-00216
SP  - 156
PY  - 2026
AB  - Precision of clinical diagnosis in neurodegenerative diseases is critically important for clinical care and study recruitment. This study aimed to investigate the clinical accuracy using gold-standard neuropathological reference.Neuropathological diagnoses from the Neurobiobank München were correlated with real-world clinical diagnoses from hospitals in Germany. Accuracy metrics, including sensitivity, specificity, and area under the curve (AUC) of clinical diagnoses, were calculated.Among nine neuropathologically diagnosed neurodegenerative diseases (Alzheimer's disease, argyrophilic grain disease, corticobasal degeneration, frontotemporal lobar degeneration, Huntington's disease, Lewy body disease, motor neuron disease, multiple system atrophy, and progressive supranuclear palsy) with a total of 455 cases, clinical sensitivity varied widely (0-100
KW  - Humans
KW  - Neurodegenerative Diseases: diagnosis
KW  - Neurodegenerative Diseases: pathology
KW  - Male
KW  - Female
KW  - Aged
KW  - Middle Aged
KW  - Autopsy
KW  - Aged, 80 and over
KW  - Sensitivity and Specificity
KW  - Adult
KW  - Clinical diagnosis (Other)
KW  - Clinical–neuropathological correlation (Other)
KW  - Diagnostic accuracy (Other)
KW  - Neurodegenerative diseases (Other)
KW  - Neuropathology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41721140
C2  - pmc:PMC12923403
DO  - DOI:10.1007/s00415-026-13680-w
UR  - https://pub.dzne.de/record/285350
ER  -