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@ARTICLE{Oelschlegel:285351,
      author       = {Oelschlegel, Anja M and Pöpplau, Jastyn A and Ryzynski,
                      Alexandre and Hradsky, Johannes and Reddy, Pasham
                      Parameshwar and Navarro, Gemma and Reyes-Resina, Irene and
                      Yuanxiang, PingAn and Sosulina, Liudmila and Kaneko, Hiroshi
                      and Sahu, Giriraj and Günther, Anne and Andres-Alonso,
                      Maria and Lopez-Rojas, Jeffrey and Aly, Ahmed A A and Bauer,
                      Pavol and Mikulovic, Sanja and Xia, Zifeng and Mikhaylova,
                      Marina and Remy, Stefan and Hanganu-Opatz, Ileana and
                      Karpova, Anna and Kreutz, Michael R},
      title        = {{E}levated calneuron-1, an accessory subunit of muscarinic
                      receptors, induces frontotemporal dysconnectivity and
                      schizophrenia-like deficits.},
      journal      = {Neuron},
      volume       = {114},
      number       = {4},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DZNE-2026-00217},
      pages        = {679 - 698.e11},
      year         = {2026},
      abstract     = {Calneuron-1 is a Ca2+ sensor that has been linked in
                      several genome-wide association studies to schizophrenia
                      (SCZ). We show that calneuron-1 expression is elevated in
                      the dorsolateral prefrontal cortex of SCZ patients and that
                      overexpression in the medial prefrontal cortex (mPFC) of
                      mice elicits SCZ-related behavioral disabilities, disrupts
                      rhythmogenesis within the mPFC, impairs functional
                      connectivity between the hippocampus and the mPFC, and
                      causes deficits in muscarinic synaptic plasticity. These
                      neurophysiological signatures of SCZ are linked to the role
                      of calneuron-1 as an accessory subunit of muscarinic M1
                      receptors (M1Rs). Calneuron-1 displaces Gαq11 from the
                      third intracellular loop of M1R at elevated [Ca2+]i, thereby
                      disrupting downstream signaling. The M1R agonist xanomeline,
                      shown to reduce positive and negative symptoms of SCZ and
                      recently approved for clinical use, impedes this
                      calneuron-1/M1R interaction, which leads to restoration of
                      G-protein coupling, muscarinic synaptic plasticity, and
                      network communication. Collectively, our data indicate a
                      potential causative pathomechanism of SCZ.},
      keywords     = {Animals / Mice / Humans / Schizophrenia: metabolism /
                      Schizophrenia: genetics / Schizophrenia: physiopathology /
                      Receptor, Muscarinic M1: metabolism / Receptor, Muscarinic
                      M1: agonists / Prefrontal Cortex: metabolism / Male /
                      Neuronal Plasticity: physiology / Neuronal Plasticity: drug
                      effects / Female / Hippocampus: metabolism / Hippocampus:
                      physiopathology / Mice, Inbred C57BL / Thiadiazoles:
                      pharmacology / Pyridines / Calneuron-1 (Other) / medial
                      prefrontal cortex (Other) / muscarinic M1 receptors (Other)
                      / schizophrenia (Other) / xanomeline (Other) / Receptor,
                      Muscarinic M1 (NLM Chemicals) / xanomeline (NLM Chemicals) /
                      Thiadiazoles (NLM Chemicals) / Pyridines (NLM Chemicals)},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41412129},
      doi          = {10.1016/j.neuron.2025.10.038},
      url          = {https://pub.dzne.de/record/285351},
}