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| Home > In process > Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits. > print |
| Home > In process > Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits. > print |
| 001 | 285351 | ||
| 005 | 20260225104617.0 | ||
| 024 | 7 | _ | |a 10.1016/j.neuron.2025.10.038 |2 doi |
| 024 | 7 | _ | |a pmid:41412129 |2 pmid |
| 024 | 7 | _ | |a 0896-6273 |2 ISSN |
| 024 | 7 | _ | |a 1097-4199 |2 ISSN |
| 037 | _ | _ | |a DZNE-2026-00217 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Oelschlegel, Anja M |b 0 |
| 245 | _ | _ | |a Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits. |
| 260 | _ | _ | |a [Cambridge, Mass.] |c 2026 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1772011998_9599 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Calneuron-1 is a Ca2+ sensor that has been linked in several genome-wide association studies to schizophrenia (SCZ). We show that calneuron-1 expression is elevated in the dorsolateral prefrontal cortex of SCZ patients and that overexpression in the medial prefrontal cortex (mPFC) of mice elicits SCZ-related behavioral disabilities, disrupts rhythmogenesis within the mPFC, impairs functional connectivity between the hippocampus and the mPFC, and causes deficits in muscarinic synaptic plasticity. These neurophysiological signatures of SCZ are linked to the role of calneuron-1 as an accessory subunit of muscarinic M1 receptors (M1Rs). Calneuron-1 displaces Gαq11 from the third intracellular loop of M1R at elevated [Ca2+]i, thereby disrupting downstream signaling. The M1R agonist xanomeline, shown to reduce positive and negative symptoms of SCZ and recently approved for clinical use, impedes this calneuron-1/M1R interaction, which leads to restoration of G-protein coupling, muscarinic synaptic plasticity, and network communication. Collectively, our data indicate a potential causative pathomechanism of SCZ. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Calneuron-1 |2 Other |
| 650 | _ | 7 | |a medial prefrontal cortex |2 Other |
| 650 | _ | 7 | |a muscarinic M1 receptors |2 Other |
| 650 | _ | 7 | |a schizophrenia |2 Other |
| 650 | _ | 7 | |a xanomeline |2 Other |
| 650 | _ | 7 | |a Receptor, Muscarinic M1 |2 NLM Chemicals |
| 650 | _ | 7 | |a xanomeline |0 9ORI6L73CJ |2 NLM Chemicals |
| 650 | _ | 7 | |a Thiadiazoles |2 NLM Chemicals |
| 650 | _ | 7 | |a Pyridines |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Schizophrenia: metabolism |2 MeSH |
| 650 | _ | 2 | |a Schizophrenia: genetics |2 MeSH |
| 650 | _ | 2 | |a Schizophrenia: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Receptor, Muscarinic M1: metabolism |2 MeSH |
| 650 | _ | 2 | |a Receptor, Muscarinic M1: agonists |2 MeSH |
| 650 | _ | 2 | |a Prefrontal Cortex: metabolism |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Neuronal Plasticity: physiology |2 MeSH |
| 650 | _ | 2 | |a Neuronal Plasticity: drug effects |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: metabolism |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Thiadiazoles: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Pyridines |2 MeSH |
| 700 | 1 | _ | |a Pöpplau, Jastyn A |b 1 |
| 700 | 1 | _ | |a Ryzynski, Alexandre |b 2 |
| 700 | 1 | _ | |a Hradsky, Johannes |b 3 |
| 700 | 1 | _ | |a Reddy, Pasham Parameshwar |b 4 |
| 700 | 1 | _ | |a Navarro, Gemma |b 5 |
| 700 | 1 | _ | |a Reyes-Resina, Irene |b 6 |
| 700 | 1 | _ | |a Yuanxiang, PingAn |b 7 |
| 700 | 1 | _ | |a Sosulina, Liudmila |0 P:(DE-2719)2810715 |b 8 |
| 700 | 1 | _ | |a Kaneko, Hiroshi |b 9 |
| 700 | 1 | _ | |a Sahu, Giriraj |b 10 |
| 700 | 1 | _ | |a Günther, Anne |b 11 |
| 700 | 1 | _ | |a Andres-Alonso, Maria |b 12 |
| 700 | 1 | _ | |a Lopez-Rojas, Jeffrey |b 13 |
| 700 | 1 | _ | |a Aly, Ahmed A A |b 14 |
| 700 | 1 | _ | |a Bauer, Pavol |b 15 |
| 700 | 1 | _ | |a Mikulovic, Sanja |b 16 |
| 700 | 1 | _ | |a Xia, Zifeng |b 17 |
| 700 | 1 | _ | |a Mikhaylova, Marina |b 18 |
| 700 | 1 | _ | |a Remy, Stefan |0 P:(DE-2719)2810375 |b 19 |u dzne |
| 700 | 1 | _ | |a Hanganu-Opatz, Ileana |b 20 |
| 700 | 1 | _ | |a Karpova, Anna |b 21 |
| 700 | 1 | _ | |a Kreutz, Michael R |0 P:(DE-2719)2811905 |b 22 |e Last author |u dzne |
| 773 | _ | _ | |a 10.1016/j.neuron.2025.10.038 |g Vol. 114, no. 4, p. 679 - 698.e11 |0 PERI:(DE-600)2001944-0 |n 4 |p 679 - 698.e11 |t Neuron |v 114 |y 2026 |x 0896-6273 |
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